抗体

大鼠抗小鼠CD71-UNLB

MBS673434

0.5毫克

260美元

单克隆

大鼠

未共轭

RI7217

免疫沉淀, 流式细胞仪

二抗

大鼠抗小鼠CD71-UNLB

CD71

Rat Anti-Mouse CD71 - Purified, Unlabeled Antibody; Rat Anti-Mouse CD71

单克隆

Rat IgG2a kappa

RI7217

大鼠

小鼠

CD71/transferrin receptor, Mr 180-190 kDa (90-95 kDa under reducing conditions). CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the transferrin receptor. It is essential for the growth of normal and neoplastic cells.^1, 4 It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens, presumably reflecting the iron dependence of proliferation.^4 Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron, which is essential for many metabolic pathways, through the binding and endocytosis of transferrin, the major ironcarrying protein. It may also be involved in signal transduction via its association with the T cell receptor zeta chain. The monoclonal antibody RI7217 inhibits cell proliferation in vitro.^2

纯化(UNLB)抗体

The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2-8 degree C. The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C. The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C. The R-phycoerythrin (R-PE) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze! . The low endotoxin, azide-free (LE/AF) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS. Aliquot and store at or below -20 degree C. Protect conjugated forms from light. Aliquot and freeze the low endotoxin, azide-free product at -20 degree C immediately upon receipt. Each reagent is stable for the period shown on the bottle label if stored as directed.

流式细胞仪;免疫沉淀

Research Application(s): In vivo and vitro inhibition of cell proliferation

Characterization: To ensure lot-to-lot consistency, each batch of monoclonal antibody is tested by flow cytometry to conform to characteristics of a standard reference reagent. Representative data are included in this product insert.

1. Lesley, J., R. Hyman, R. Schulte, and J. Trotter. 1984. Cell Immunol. 83:14. 2. Kemp, J. D., J. A. Thorson, F. Gomez, K. M. Smith, J. S. Cowdery, and Z. K. Ballas. 1989. Cell Immunol. 122:218. 3. Lesley, J.F., and R.J. Schulte. 1985. Mol. Cell. Biol. 5:1814. 4. Kemp, J. D., J. A. Thorson, T. H. McAlmont, M. Horowitz, J. S. Cowdery, and Z. K. Ballas. 1987. J. Immunol. 138:2422. 5. Sauvage, C.A., J.C. Mendelsohn, J.F. Lesley, and I.S. Trowbridge. 1987. Cancer Res. 47:747.

0.5毫克

260美元