Rat Anti-Mouse MHC Class II-UNLB | MyBioSource MBS673637 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

Rat Anti-Mouse MHC Class II-UNLB

MBS673637

规格 :

0.5毫克

价格 :

300美元

克隆性 :

单克隆

宿主 :

大鼠

共轭标签 :

未共轭

克隆名称 :

NIMR-4

反应物种 :

人类, 小鼠

应用 :

流式细胞仪

更多信息或购买 :

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产品信息

目录号 :

MBS673637

产品类型 :

二抗

产品全称 :

Rat Anti-Mouse MHC Class II-UNLB

产品简称 :

MHC Class II

产品名称同义词 :

Rat Anti-Mouse MHC Class II - Purified, Unlabeled Antibody; Rat Anti-Mouse MHC Class II

其他名称 :

MHC class II; MHC class II HLA-DQ-beta-1; HLA class II histocompatibility antigen, DQ beta 1 chain; MHC DQ beta; MHC class2 antigen; OTTHUMP00000029167; OTTHUMP00000178569; OTTHUMP00000178570; OTTHUMP00000178571; lymphocyte antigen; MHC class II antigen DQB1; MHC class II DQ beta chain; MHC class II antigen HLA-DQ-beta-1; MHC class II HLA-DQ beta glycoprotein; major histocompatibility complex class II beta; HLA class II histocompatibility antigen, DQ beta 1 chain-like; major histocompatibility complex, class II, DQ beta 1

其他基因名称 :

HLA-DQB1;HLA-DQB1;IDDM1;CELIAC1;HLA-DQB

UniProt数据库进入名 :

O19707_HUMAN

克隆性 :

单克隆

抗体亚型 :

大鼠IgG2b

克隆 :

NIMR-4

宿主 :

大鼠

反应物种 :

小鼠

序列长度 :

229

特异性 :

MHC Class II molecules. The monoclonal antibody NIMR-4 reacts specifically with a non-polymorphic I-A-encoded epitope on MHC Class II antigens. Class II antigens are predominantly expressed on antigen-presenting cells including B lymphocytes, macrophages, dendritic cells and certain epithelial cells.

形式 :

纯化(UNLB)抗体

储存稳定性 :

The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C. The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C. The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C. The R-phycoerythrin (R-PE) conjugate is supplied as 0.1 mg in 1.0 mL or 0.2 mg in 2.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze! . The Spectral Red (SPRD) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze! . The low endotoxin, azide-free (LE/AF) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of PBS. Aliquot and store at or below -20 degree C. Protect conjugated forms from light. Aliquot and freeze the low endotoxin, azide-free product at -20 degree C immediately upon receipt. Each reagent is stable for the period shown on the bottle label if stored as directed.

检测过的应用 :

流式细胞仪

应用笔记 :

Research Application(s): Complement-dependent cytotoxicity assays. Flow Cytometry Suggested Dilution: <=1 ug/10^6 cells

其他信息2 :

Characterization: To ensure lot-to-lot consistency, each batch of product is tested by flow cytometry to conform to characteristics of a standard reference reagent. Representative data are included in this product insert.

产品引用 :

1. R.M.E. Parkhouse. 1996. Personal communication.

NCBI GI登录号 :

1160938

UniProt数据库登录号 :

O19707

NCBI分子量 :

26,489 Da

NCBI信号通路 :

Adaptive Immunity Signaling Pathway (366160); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Asthma Pathway (83120); Asthma Pathway (532); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Cell Adhesion Molecules (CAMs) Pathway (83069)

NCBI总结 :

HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq]

UniProt数据库总结 :

Sequence similarities: Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS014745

尺寸1 :

0.5毫克

价格1 :

300美元

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公司信息