抗体

抗-肌动蛋白

MBS684023

0.1 ml Concentrate

430美元

单克隆

兔

nonconjugated

S12-I

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫沉淀, 酶免疫法

抗体

抗-肌动蛋白

肌动蛋白

Actin, cytoplasmic 1; Actin, cytoplasmic 1; actin, cytoplasmic 1; beta cytoskeletal actin; PS1TP5-binding protein 1; actin, beta; Beta-actin

ACTB;ACTB;BRWS1;PS1TP5BP1

ACTB_HUMAN

单克隆

S12-I

兔

人类, 小鼠, 大鼠

375

人类, 大鼠, 小鼠试验

Store at -20 degree C

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫沉淀(免疫沉淀)

免疫印迹-1:2 000, 酶联免疫吸附测定-1:10 000-1:20 000

Immunogen: Peptide derived from C-terminal peptide of human beta-actin. Storage Buffer: 20 mM Tris-HCI, pH 8.0. Stabilizer: 10 mg/ml BSA

Preservative: 0.05% NaN3. Regulatory Status: ISO 9001:2008, ISO 13485:2003, CE

46397333

P60709.1

P60709

41,737 Da

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]

Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Subunit structure: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCSAM. Ref.11 Ref.12 Ref.14 Ref.15 Ref.16 Ref.18 Ref.21. Subcellular location: Cytoplasm cytoskeleton. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Ref.15. Post-translational modification: ISGylated. Ref.13Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization . By similarity.Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. Involvement in disease: Dystonia, juvenile-onset (DYTJ) [MIM:607371]: A form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. Patients with juvenile-onset dystonia manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.20Baraitser-Winter syndrome 1 (BRWS1) [MIM:243310]: A rare developmental disorder characterized by the combination of congenital ptosis, high-arched eyebrows, hypertelorism, ocular colobomata, and a brain malformation consisting of anterior-predominant lissencephaly. Other typical features include postnatal short stature and microcephaly, intellectual disability, seizures, and hearing loss.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23. Miscellaneous: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Sequence similarities: Belongs to the actin family.

0.1 ml Concentrate

430美元