抗体

仓鼠抗小鼠CD40配体

MBS690292

0.1毫克

490美元

单克隆

仓鼠

未共轭

[(MAB0712)]

免疫组化, 流式细胞仪, 流式细胞仪

抗体

仓鼠抗小鼠CD40配体

[CD40配体]

[Cd40lg; IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; CD40-L; Tnfsf5]

[CD40 ligand; CD40 ligand; CD40 ligand; T-cell antigen Gp39; TNF-related activation protein; tumor necrosis factor ligand superfamily member 5; CD40 ligand; T-cell antigen Gp39; TNF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5]

[CD40配体]

[Cd40lg; Cd40lg; IGM; IMD3; Ly62; TRAP; gp39; CD154; Cd40l; HIGM1; Ly-62; T-BAM; CD40-L; Tnfsf5; Cd40l; Tnfsf5; CD40-L; TRAP]

CD40L_MOUSE

单克隆

IgG2

[(MAB0712)]

仓鼠

小鼠

260

蛋白质A/G亲和色谱

冻干

Stability: Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity. Ships Room Temperature or 4 degree C.

免疫组化(免疫组化), 流式细胞仪(FC/流式细胞仪)

IHC (paraffine): 1:100-1:300. Flow cytometry: 1:100-1:1000. This antibody was selected for its ability to detect mouse CD40 Ligand.

免疫组化

免疫组化

Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a Armenian Hamster) immunized with mouse Th1 cells. IgG2 fraction of the culture supernatant was purified by Protein G affinity chromatography.

Reconstitution: Reconstitute the antibody with 400 ul sterile PBS and the final concentration is 500 ug/ml. Antigen: Mouse Th1 cells . Reconstitution buffer: PBS (sterile)

CD40 ligand (CD40L), also known as CD154, TNFSF5, TRAP or gp39, is a 260 amino acid type II transmembrane glycoprotein belonging to the TNF family. Murine CD40L consists of a 22 aa cytoplasmic domain, a 24 aa transmembrane domain, and 214 aa extracellular domain bearing a single glycosylation site. CD40L is expressed predominantly on activated CD4+ T lymphocytes, and also found in other types of cells, including NK cells, mast cells, basophils and eosinophils. Murine CD40L shares 78% amino acid sequence identity with human CD40L. Native bioactive soluble CD40L exists. Soluble human trimeric CD40L secreted by stimulated T cells has been shown to be generated by proteolysis in the microsomes. Both membrane bound and soluble CD40L induce similar effects on B cells.

15011846

NP_035746.2

NM_011616.2

P27548

29,370 Da

Adaptive Immune System Pathway (926013); Allograft Rejection Pathway (83316); Allograft Rejection Pathway (535); Asthma Pathway (83313); Asthma Pathway (532); Autoimmune Thyroid Disease Pathway (83314); Autoimmune Thyroid Disease Pathway (533); Cell Adhesion Molecules (CAMs) Pathway (83266); Cell Adhesion Molecules (CAMs) Pathway (480); Cytokine-cytokine Receptor Interaction Pathway (83248)

Function: Cytokine that binds to TNFRSF5. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching . By similarity. Subunit structure: Homotrimer. Subcellular location: Cell membrane; Single-pass type II membrane protein. CD40 ligand, soluble form: Secreted. Tissue specificity: Specifically expressed on activated CD4+ T-lymphocytes. Post-translational modification: The soluble form derives from the membrane form by proteolytic processing . By similarity. Sequence similarities: Belongs to the tumor necrosis factor family.

0.1毫克

490美元