产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
大鼠抗小鼠CD45R(B220)
目录 :
MBS690362
规格 :
0.1毫克
价格 :
475美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
(9F14)
反应物种 :
小鼠
应用 :
免疫组化, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
产品信息
目录号 :
MBS690362
产品类型 :
抗体
产品全称 :
大鼠抗小鼠CD45R(B220)
产品简称 :
CD45受体(B220)
产品名称同义词 :
抗小鼠CD45R(B220)(#9F14)
其他名称 :
Receptor-type tyrosine-protein phosphatase C; Receptor-type tyrosine-protein phosphatase C; receptor-type tyrosine-protein phosphatase C; lymphocyte antigen 5; leukocyte common antigen; lymphocyte common antigen; protein tyrosine phosphatase, receptor type, C; Leukocyte common antigen; L-CA; Lymphocyte antigen 5; Ly-5; T200
产品基因名称 :
CD45受体(B220)
其他基因名称 :
Ptprc; Ptprc; loc; B220; Cd45; L-CA; Ly-5; T200; CD45R; Lyt-4; Ly-5; L-CA; Ly-5
UniProt数据库进入名 :
PTPRC_MOUSE
克隆性 :
单克隆
抗体亚型 :
IgG2
克隆 :
(9F14)
宿主 :
大鼠
反应物种 :
小鼠
序列长度 :
1291
特异性 :
CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity.
纯度 :
蛋白质G/A亲和色谱
形式 :
冻干
储存稳定性 :
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity. Shipping: Ships on coldpacks
检测过的应用 :
免疫组化(P):免疫组化(石蜡)。 FC:流式细胞仪
应用笔记 :
Flow cytometry: 1:100-1:400. IHC (paraffin): 1:50-1:200
其它信息1 :
Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse Leukemia virus-induced pre-B tumor cells. IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography. Antigen: Leukemia virus-induced pre-B tumor cells.
其他信息2 :
Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. Reconstitution Buffer: PBS (Sterile). Target: B220. Remarks: This antibody was selected for its ability to detect mouse CD45R
产品描述 :
CD45R is an isoform of CD45, also known as B220. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, subsets of T and NK cells.
NCBI GI登录号 :
341942176
NCBI登录号 :
NP_001104786.2
UniProt数据库登录号 :
P06800
NCBI信号通路 :
Adaptive Immune System Pathway (926013); Axon Guidance Pathway (926383); B Cell Receptor Signaling Pathway (198285); Cell Adhesion Molecules (CAMs) Pathway (83266); Cell Adhesion Molecules (CAMs) Pathway (480); Developmental Biology Pathway (926382); EPO Receptor Signaling Pathway (198317); Fc Gamma R-mediated Phagocytosis Pathway (114297); Fc Gamma R-mediated Phagocytosis Pathway (106590); Immune System Pathway (926012)
UniProt数据库总结 :
Function: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN . By similarity. Dephosphorylates LYN, and thereby modulates LYN activity. Ref.14. Catalytic activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. Subunit structure: Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes . By similarity. Binds GANAB and PRKCSH. Ref.13. Subcellular location: Membrane; Single-pass type I membrane protein. Membrane raft . By similarity. Note: Colocalized with DPP4 in membrane rafts . By similarity. Developmental stage: Expression is restricted to the hematopoietic compartment of development. Domain: The first PTPase domain interacts with SKAP1 . By similarity. Post-translational modification: Heavily N- and O-glycosylated. Sequence similarities: Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.Contains 2 fibronectin type-III domains.Contains 2 tyrosine-protein phosphatase domains. Sequence caution: The sequence AAA39462.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
尺寸1 :
0.1毫克
价格1 :
475美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。