产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
兔抗人类NRP-1
目录 :
MBS691201
规格 :
0.2毫克
价格 :
390美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹
更多信息或购买 :
产品信息
目录号 :
MBS691201
产品类型 :
抗体
产品全称 :
兔抗人类NRP-1
产品简称 :
NRP-1
产品名称同义词 :
神经纤毛蛋白受体1;VEGF165R;NRP;CD307;神经纤毛蛋白受体1;VEGF165R;NRP;CD304
其他名称 :
neuropilin-1 isoform b; Neuropilin-1; neuropilin-1; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; neuropilin 1; Vascular endothelial cell growth factor 165 receptor
产品基因名称 :
NRP-1
其他基因名称 :
NRP1;NRP1;NP1;NRP;BDCA4;CD304;VEGF165R;NRP;VEGF165R
UniProt数据库进入名 :
NRP1_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
ND
序列长度 :
644
纯度 :
蛋白质A纯化
形式 :
冻干
储存稳定性 :
The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 degree C. Frozen aliquots are stable for at least 6 months when stored at -20 degree C.
检测过的应用 :
免疫印迹(免疫印迹)
应用笔记 :
Western Blot: Use at 1-5 ug/ml. ELISA: use at 1-5 ug/ml. IF/IHC: use at 1-5 ug/ml(IF on cells). FACS: use at 1-5 ug/ml
其它信息1 :
Antigen: Recombinant human NRP-1 (RT #S01-019)
其他信息2 :
Buffer: PBS. Reconstition: Centrifuge wial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml
NCBI GI登录号 :
66912178
NCBI登录号 :
NP_001019799.1
NCBI基因登录号 :
NM_001024628.2
UniProt数据库登录号 :
O14786
NCBI分子量 :
103,134 Da
NCBI信号通路 :
Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); CHL1 Interactions Pathway (161007); CRMPs In Sema3A Signaling Pathway (119525); Developmental Biology Pathway (477129); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); L1CAM Interactions Pathway (161003); Neurophilin Interactions With VEGF And VEGFR Pathway (106509)
NCBI总结 :
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
UniProt数据库总结 :
Function: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform ofPGF, The VEGF-165 isoform ofVEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. Subunit structure: Homodimer, and heterodimer with NRP2. Interacts with FER . By similarity. Binds PLXNB1. Ref.10 Ref.16. Subcellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Tissue specificity: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Domain: The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding. Sequence similarities: Belongs to the neuropilin family.Contains 2 CUB domains.Contains 2 F5/8 type C domains.Contains 1 MAM domain.
尺寸1 :
0.2毫克
价格1 :
390美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。