抗体

PDE6D抗体

MBS7005086

0.05毫克

160美元

多克隆

兔

未共轭

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

PDE6D抗体

[PDE6D]

[Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDEdelta) (Proteinp17), PDE6D, PDED]

[retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform 2; Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; phosphodiesterase 6D; Protein p17]

[PDE6D]

[PDE6D; PDE6D; PDED; JBTS22; PDED; GMP-PDE delta]

PDE6D_HUMAN

多克隆

IgG

兔

人类

抗原亲和纯化

液体

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)

Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

免疫印迹(免疫印迹)

免疫组化(免疫组化)

免疫组化(免疫组化)

Immunogen: Recombinant Human Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta protein (1-150AA). Conjugate: Non-conjugated. Storage Buffer: Preservative:0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Species: Human. Research Area: Signal Transduction

Promotes the release of prenylated target proteins from cellular membranes (PubMed:9712853). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22002721, PubMed:23698361). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (PubMed:24166846). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity).

597518021

NP_001277947.1

NM_001291018.1

O43924

ARL13B-mediated Ciliary Trafficking Of INPP5E Pathway (1268852); Assembly Of The Primary Cilium Pathway (1268846); Cargo Trafficking To The Periciliary Membrane Pathway (1268848); Organelle Biogenesis And Maintenance Pathway (1268838); Purine Metabolism Pathway (82944); Purine Metabolism Pathway (307)

This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants. [provided by RefSeq, Mar 2014]

PDE6D: Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation. Belongs to the PDE6D/unc-119 family. Chromosomal Location of Human Ortholog: 2q35-q36. Cellular Component: cytoplasmic vesicle; cytoplasmic vesicle membrane; cytoskeleton; cytosol. Molecular Function: 3',5'-cyclic-nucleotide phosphodiesterase activity; GTPase inhibitor activity; protein binding; Rab GTPase binding. Biological Process: metabolic process; organelle organization and biogenesis; response to stimulus; visual perception. Disease: Joubert Syndrome 22

0.05毫克

160美元

0.1毫克

235