产品简要
公司名称 :
MyBioSource
产品类型 :
ELISA/assay
产品名称 :
人类整合素beta2, ITG beta2/CD11+CD18酶联免疫吸附试剂盒
目录 :
MBS704374
规格 :
48-Strip-Wells
价格 :
510美元
更多信息或购买 :
产品信息
目录号 :
MBS704374
产品类型 :
酶联免疫吸附试剂盒
产品全称 :
人类整合素beta2, ITG beta2/CD11+CD18酶联免疫吸附试剂盒
产品简称 :
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
产品名称同义词 :
Human integrin beta2; ITG beta2/CD11+CD18 ELISA Kit; CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7; OTTHUMP00000115279; OTTHUMP00000115281; OTTHUMP00000115282; cell surface adhesion glycoprotein LFA-1/CR3/P150; 959 beta subunit precursor) ; complement receptor; integrin; beta 2 (complement component 3 receptor 3 and 4 subunit)
其他名称 :
integrin beta-2; Integrin beta-2; integrin beta-2; integrin beta chain, beta 2; complement receptor C3 beta-subunit; complement receptor C3 subunit beta; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor); integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18
产品基因名称 :
ITGB2
其他基因名称 :
ITGB2;ITGB2;LAD;CD18;MF17;MFI7;LCAMB;LFA-1;MAC-1;CD18;MFI7
UniProt数据库进入名 :
ITB2_HUMAN
反应物种 :
人类
序列长度 :
769
特异性 :
This assay has high sensitivity and excellent specificity for detection of Human ITGB2. No significant cross-reactivity or interference between Human ITGB2 and analogues was observed.
储存稳定性 :
Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
其它信息1 :
Assay Type: Sandwich
其他信息2 :
Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul. Protein Biological Process 1: Cell Adhesion. Protein Biological Process 3: Cell adhesion
产品描述 :
Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for ITG beta2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any ITG beta2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ITG beta2 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ITG beta2 bound in the initial step. The color development is stopped and the intensity of the color is measured.
NCBI GI登录号 :
89191865
NCBI登录号 :
NP_000202.2
NCBI基因登录号 :
NM_000211.3
UniProt数据库登录号 :
P05107
NCBI分子量 :
84,782 Da
NCBI信号通路 :
Adaptive Immune System Pathway (366160); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); CXCR3-mediated Signaling Events Pathway (138011); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (106062); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795); HIF-1-alpha Transcription Factor Network Pathway (138045)
NCBI总结 :
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
Function: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.1 PublicationManual assertion based on experiment in:Ref.15
尺寸1 :
48-Strip-Wells
价格1 :
510美元
尺寸2 :
96-Strip-Wells
价格2 :
725
size3 :
5x96-Strip-Wells
价格3 :
2565
size4 :
10x96-Strip-Wells
price4 :
4800
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。