产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
MEF2D抗体
目录 :
MBS7050075
规格 :
0.05毫克
价格 :
160美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法
更多信息或购买 :
图像
图像 1 :
Western Blot. Positive WB detected in: Hela whole cell lysate,HepG2 whole cell lysate,A549 whole cell lysate,Mouse heart tissue. All lanes: MEF2D antibody at 2.7ug/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 56,57,51,50 KDa. Observed band size: 56 KDa.
图像 2 :
IHC image of MBS7050075 diluted at 1:400 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 degree C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
图像 3 :
IHC image of MBS7050075 diluted at 1:400 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 degree C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
产品信息
目录号 :
MBS7050075
产品类型 :
抗体
产品全称 :
MEF2D抗体
产品简称 :
[MEF2D]
产品名称同义词 :
[Myocyte-specific enhancer factor 2D; MEF2D]
其他名称 :
[myocyte-specific enhancer factor 2D isoform 2; Myocyte-specific enhancer factor 2D; myocyte-specific enhancer factor 2D; myocyte enhancer factor 2D]
产品基因名称 :
[MEF2D]
其他基因名称 :
[MEF2D;MEF2D]
UniProt数据库进入名 :
MEF2D_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
兔
反应物种 :
人类, 小鼠
序列长度 :
514
纯度 :
>95%, Protein G purified
形式 :
液体
储存稳定性 :
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
检测过的应用 :
酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
WB: 1: 500-1: 5000。 IHC: 1: 20-1: 200
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
image3头 :
免疫组化(免疫组化)
其它信息1 :
Immunogen: Recombinant Human Myocyte-specific enhancer factor 2D protein (299-509AA). Species: Human. Research Area: Neuroscience
其他信息2 :
Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, pH 7.4. Conjugation: Non-conjugated. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-13921
产品描述 :
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity).
NCBI GI登录号 :
410442515
NCBI登录号 :
NP_001258558.1
NCBI基因登录号 :
NM_001271629.1
UniProt数据库登录号 :
Q14814
NCBI分子量 :
49,856 Da
NCBI信号通路 :
Adipogenesis Pathway (198832); B Cell Receptor Signaling Pathway (198909); CDO In Myogenesis Pathway (1270336); Cell Differentiation - Index Pathway (1458245); Circadian Clock Pathway (1269871); Developmental Biology Pathway (1270302); EGF/EGFR Signaling Pathway (198782); Mitochondrial Biogenesis Pathway (1268839); Myogenesis Pathway (1270335); Organelle Biogenesis And Maintenance Pathway (1268838)
NCBI总结 :
This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
UniProt数据库总结 :
MEF2D: transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in muscle-specific and/or growth factor-related transcription. Six splice-variant isoforms have been described. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 1q12-q23. Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus. Molecular Function: histone deacetylase binding; protein binding; transcription activator binding. Biological Process: adult heart development; muscle development; positive regulation of transcription from RNA polymerase II promoter
尺寸1 :
0.05毫克
价格1 :
160美元
尺寸2 :
0.1毫克
价格2 :
235
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。