抗体

Rabbit anti-human integrin, alpha X (complement component 3 receptor 4 subunit) polyclonal Antibody

MBS710275

0.05毫升

375美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫细胞化学, 酶免疫法

抗体

Rabbit anti-human integrin, alpha X (complement component 3 receptor 4 subunit) polyclonal Antibody

整合素, 甲X

integrin; alpha X (complement component 3 receptor 4 subunit); ITGAX; CD11C; SLEB6

integrin, alpha X (complement component 3 receptor 4 subunit), isoform CRA_b; Integrin alpha-X; integrin alpha-X; leu M5, alpha subunit; p150 95 integrin alpha chain; CD11 antigen-like family member C; leukocyte adhesion receptor p150,95; myeloid membrane antigen, alpha subunit; leukocyte surface antigen p150,95, alpha subunit; leukocyte adhesion glycoprotein p150,95 alpha chain; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit); CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD_antigen: CD11c

ITGAX;ITGAX;CD11C;SLEB6;CD11C

ITAX_HUMAN

多克隆

IgG

兔

Human,Mouse,Rat; Other species are not tested. Please decide the specificity by homology.

719

抗原亲和纯化

液体

Shipped at 4 Degree C Upon delivery aliquot and store at -20 Degree C or -80 Degree C. Avoid repeated freeze.

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫荧光(IF)

ELISA:Use at an assay dependent dilution. WB : 1:200-1:2000. IHC : 1:20-1:200 (Recommender dilutions). Positive WB detected in: Human blood tissue . Positive IHC detected in: Human spleen tissue

Immunogen: Human ITGAX. Conjugate : Non-conjugated

Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

119572526

EAW52141.1

127,829 Da

Cell Surface Interactions At The Vascular Wall Pathway (106062); ECM Proteoglycans Pathway (833812); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795); Hemostasis Pathway (106028); Integrin Cell Surface Interactions Pathway (106110); Integrin-mediated Cell Adhesion Pathway (198816); Regulation Of Actin Cytoskeleton Pathway (83089); Regulation Of Actin Cytoskeleton Pathway (500); Tuberculosis Pathway (213780)

This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

ITGAX: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Belongs to the integrin alpha chain family. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: cell surface; membrane; plasma membrane; integrin complex. Molecular Function: protein binding; metal ion binding; receptor activity. Biological Process: integrin-mediated signaling pathway; heterotypic cell-cell adhesion; organ morphogenesis; extracellular matrix organization and biogenesis; cell adhesion; blood coagulation; leukocyte migration. Disease: Systemic Lupus Erythematosus

0.05毫升

375美元

0.15毫升

715