抗体

Rabbit anti-human X-linked inhibitor of apoptosis polyclonal Antibody

MBS711171

0.05毫升

375美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 酶免疫法

抗体

Rabbit anti-human X-linked inhibitor of apoptosis polyclonal Antibody

X-linked inhibitor of apoptosis

X-linked inhibitor of apoptosis; XIAP; API3; BIRC4; ILP1; MIHA; XLP2

X-linked inhibitor of apoptosis; E3 ubiquitin-protein ligase XIAP; E3 ubiquitin-protein ligase XIAP; X-linked IAP; IAP-like protein; inhibitor of apoptosis protein 3; baculoviral IAP repeat-containing protein 4; X-linked inhibitor of apoptosis; Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; X-linked inhibitor of apoptosis protein; X-linked IAP

XIAP;XIAP;API3;ILP1;MIHA;XLP2;BIRC4;IAP-3;hIAP3;hIAP-3;API3;BIRC4;IAP3;ILP;hILP;IAP-3;hIAP-3;hIAP3;X链接IAP

XIAP_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

497

蛋白质A纯化

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF)

Immunogen: Human XIAP

Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

21619764

AAH32729.1

56,685 Da

Apoptosis Pathway (198797); Apoptosis Pathway (83060); Apoptosis Pathway (470); Apoptosis Pathway (105648); Apoptotic Factor-mediated Response Pathway (105669); BMP Receptor Signaling Pathway (137948); Caspase Cascade In Apoptosis Pathway (137974); Disease Pathway (530764); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478)

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

XIAP: an apoptotic suppressor protein. Inhibist apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. Inhibits cell-death proteases, caspase-3, caspase-7, and perhaps caspase-9. Protein type: Ligase; Ubiquitin ligase; Ubiquitin conjugating system; Apoptosis; EC 6.3.2.-. Chromosomal Location of Human Ortholog: Xq25. Cellular Component: nucleoplasm; spindle microtubule; cytoplasm; cytosol; nucleus. Molecular Function: protein binding; zinc ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity; ligase activity. Biological Process: Wnt receptor signaling pathway; apoptosis; positive regulation of protein ubiquitination; regulation of BMP signaling pathway; regulation of inflammatory response; protein ubiquitination; negative regulation of caspase activity; response to DNA damage stimulus; copper ion homeostasis; regulation of cell proliferation; regulation of innate immune response; negative regulation of apoptosis. Disease: Lymphoproliferative Syndrome, X-linked, 1; Lymphoproliferative Syndrome, X-linked, 2

0.05毫升

375美元

0.15毫升

715