抗体

Rabbit anti-human solute carrier family 27 (fatty acid transporter), member 4 polyclonal Antibody

MBS711481

0.05毫升

375美元

多克隆

兔

未共轭

人类, 小鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

Rabbit anti-human solute carrier family 27 (fatty acid transporter), member 4 polyclonal Antibody

solute carrier family 27 (fatty acid transporter), member 4

solute carrier family 27 (fatty acid transporter); member 4; SLC27A4; ACSVL4; FATP4

Solute carrier family 27 (fatty acid transporter), member 4; Long-chain fatty acid transport protein 4; long-chain fatty acid transport protein 4; solute carrier family 27 (fatty acid transporter), member 4; Solute carrier family 27 member 4

SLC27A4;SLC27A4;IPS;FATP4;ACSVL4;ACSVL4;FATP4;FATP-4;脂肪酸运输蛋白4

S27A4_HUMAN

多克隆

IgG

兔

人类, 小鼠

643

抗原亲和纯化

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)

Immunogen: Human SLC27A4

Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

40675396

AAH65003.1

26,001 Da

Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450); SLC-mediated Transmembrane Transport Pathway (119558); Transmembrane Transport Of Small Molecules Pathway (106572); Transport Of Fatty Acids Pathway (187185); Transport Of Vitamins, Nucleosides, And Related Molecules Pathway (161075)

This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]

SLC27A4: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS). A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. Belongs to the ATP-dependent AMP-binding enzyme family. Protein type: Transporter, SLC family; Membrane protein, integral; Ligase; EC 6.2.1.-; Transporter; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 9q34.11. Cellular Component: endoplasmic reticulum membrane; microvillus; membrane; brush border membrane; plasma membrane; integral to membrane. Molecular Function: fatty acid transporter activity; nucleotide binding; very-long-chain-fatty-acid-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity. Biological Process: skin development; long-chain fatty acid transport; very-long-chain fatty acid catabolic process; transport; long-chain fatty acid metabolic process; lipid metabolic process; medium-chain fatty acid transport; transmembrane transport; fatty acid transport; response to nutrient. Disease: Ichthyosis Prematurity Syndrome

0.05毫升

375美元

0.15毫升

715