抗体

Rabbit anti-human interleukin 1 receptor antagonist polyclonal Antibody

MBS713314

0.05毫升

375美元

多克隆

兔

未共轭

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

Rabbit anti-human interleukin 1 receptor antagonist polyclonal Antibody

interleukin 1 receptor antagonist

interleukin 1 receptor antagonist; IL1RN; ICIL-1RA; IL-1ra3; IL1F3; IL1RA; IRAP; MGC10430

interleukin 1 receptor antagonist; Interleukin-1 receptor antagonist protein; interleukin-1 receptor antagonist protein; IL1 inhibitor; IL1RN (IL1F3); type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra); interleukin 1 receptor antagonist; ICIL-1RA; IL1 inhibitor; INN: Anakinra

IL1RN;IL1RN;DIRA;IRAP;IL1F3;IL1RA;MVCD4;IL-1RN;IL-1ra;IL-1ra3;ICIL-1RA;IL1F3;IL1RA;IL-1RN;IL-1ra;IRAP

IL1RA_HUMAN

多克隆

IgG

兔

人类

177

抗原亲和纯化

液体

Shipped at 4 degree C Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

酶联免疫吸附测定(EIA), 免疫组化(免疫组化), 免疫印迹(免疫印迹)

ELISA: Use at an assay dependent dilution. WB : 1:200-1:2000 . IHC : 1:20-1:200 (Recommender dilutions) . Positive WB detected in: Transfected HEK-293 cells . Positive IHC detected in: Human oesophagus tissue, human colon cancer tissue, human stomach tissue

Immunogen: Human IL1RN. Conjugate : Non-conjugated

Storage Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Rabbit polyclonal to IL1RN . Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

186386

AAB41943.1

Cytokine Signaling In Immune System Pathway (366171); IL-1 Signaling Pathway (198908); IL1-mediated Signaling Events Pathway (137944); Immune System Pathway (106386); Interleukin-1 Signaling Pathway (160141); Leptin Signaling Pathway (672456); SIDS Susceptibility Pathways (198901); Signaling By Interleukins Pathway (160140)

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Vesicle; Cytokine; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 2q14.2. Cellular Component: extracellular space; cytoplasm; plasma membrane; intracellular. Molecular Function: interleukin-1 Type I receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type II receptor binding; cytokine activity; interleukin-1, Type I receptor binding; interleukin-1 receptor antagonist activity. Biological Process: response to drug; positive regulation of JNK activity; negative regulation of glutamate secretion; negative regulation of heterotypic cell-cell adhesion; response to glucocorticoid stimulus; carboxylic acid metabolic process; response to lipopolysaccharide; female pregnancy; fever; sensory perception of pain; chronic inflammatory response to antigenic stimulus; memory; response to starvation; insulin secretion; acute-phase response; immune response; negative regulation of cytokine and chemokine mediated signaling pathway; lipid metabolic process; response to activity; negative regulation of membrane potential; negative regulation of cell migration; negative regulation of apoptosis. Disease: Microvascular Complications Of Diabetes, Susceptibility To, 4; Gastric Cancer, Hereditary Diffuse; Osteomyelitis, Sterile Multifocal, With Periostitis And Pustulosis

0.05毫升

375美元

0.15毫升

715