产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
兔抗人类GTPase KRas多克隆抗体, 生物素共轭标签
目录 :
MBS719647
规格 :
0.05毫克
价格 :
160美元
克隆性 :
多克隆
宿主 :
共轭标签 :
生物素
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS719647
产品类型 :
抗体
产品全称 :
兔抗人类GTPase KRas多克隆抗体, 生物素共轭标签
产品简称 :
GTPase KRas
产品名称同义词 :
K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras; KRAS; KRAS2; RASK2
其他名称 :
GTPase KRas isoform b; GTPase KRas; GTPase KRas; Kirsten rat sarcoma viral oncogene homolog; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras
其他基因名称 :
KRAS;KRAS;NS;NS3;CFC2;RALD;KRAS1;KRAS2;RASK2;KI-RAS;C-K-RAS;K-RAS2A;K-RAS2B;K-RAS4A;K-RAS4B;KRAS2;RASK2
UniProt数据库进入名 :
RASK_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类
序列长度 :
188
纯度 :
Caprylic Acid Ammonium Sulfate Precipitation Purified
储存稳定性 :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
检测过的应用 :
免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)
其它信息1 :
Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Biotin
其他信息2 :
Immunogen: Recombinant human GTPase KRas protein
产品描述 :
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
NCBI GI登录号 :
15718761
NCBI登录号 :
NP_004976.2
NCBI基因登录号 :
NM_004985.4
UniProt数据库登录号 :
P01116
NCBI分子量 :
21,425 Da
NCBI信号通路 :
AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); ARMS-mediated Activation Pathway (1269471); Activation Of RAS In B Cells Pathway (1269187); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adaptive Immune System Pathway (1269171); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Aldosterone-regulated Sodium Reabsorption Pathway (130626)
NCBI总结 :
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
KRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: G protein, monomeric; G protein; Motility/polarity/chemotaxis; G protein, monomeric, Ras; Oncoprotein. Chromosomal Location of Human Ortholog: 12p12.1. Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; lipid raft; membrane; mitochondrion; plasma membrane. Molecular Function: GDP binding; GMP binding; GTP binding; LRR domain binding; protein binding; protein complex binding. Biological Process: actin cytoskeleton organization and biogenesis; activation of MAPKK activity; activation of NF-kappaB transcription factor; axon guidance; blood coagulation; cytokine and chemokine mediated signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; forebrain astrocyte development; homeostasis of number of cells within a tissue; innate immune response; insulin receptor signaling pathway; leukocyte migration; MAPKKK cascade; negative regulation of cell differentiation; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of nitric-oxide synthase activity; positive regulation of protein amino acid phosphorylation; positive regulation of Rac protein signal transduction; Ras protein signal transduction; regulation of long-term neuronal synaptic plasticity; regulation of synaptic transmission, GABAergic; response to glucocorticoid stimulus; response to mineralocorticoid stimulus; small GTPase mediated signal transduction; social behavior; stimulatory C-type lectin receptor signaling pathway; striated muscle cell differentiation; vascular endothelial growth factor receptor signaling pathway; visual learning. Disease: Bladder Cancer; Breast Cancer; Cardiofaciocutaneous Syndrome 2; Gastric Cancer, Hereditary Diffuse; Leukemia, Acute Myeloid; Lung Cancer; Noonan Syndrome 3; Pancreatic Cancer; Schimmelpenning-feuerstein-mims Syndrome
尺寸1 :
0.05毫克
价格1 :
160美元
尺寸2 :
0.1毫克
价格2 :
235
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。