抗体

Rabbit anti-human Urokinase-type plasminogen activator polyclonal Antibody

MBS719744

0.05毫克

160美元

多克隆

兔

未共轭

酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

Rabbit anti-human Urokinase-type plasminogen activator polyclonal Antibody

Urokinase-type plasminogen activator

U纤溶酶原激活剂;uPA;PLAU

urokinase-type plasminogen activator isoform 2; Urokinase-type plasminogen activator; urokinase-type plasminogen activator; plasminogen activator, urokinase

PLAU;PLAU;ATF;QPD;UPA;URK;u-PA;BDPLT5;U纤溶酶原激活剂;uPA

UROK_HUMAN

多克隆

IgG

兔

人类

414

Caprylic Acid Ammonium Sulfate Precipitation Purified

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

酶联免疫吸附测定(EIA), 免疫组化(免疫组化)

Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Non-conjugated

Immunogen: Recombinant human Urokinase-type plasminogen activator protein

Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.

222537759

NP_001138503.1

NM_001145031.2

P00749

46,908 Da

ATF-2 Transcription Factor Network Pathway (138006); Blood Clotting Cascade Pathway (198840); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); DNA Damage Response (only ATM Dependent) Pathway (198827); Dissolution Of Fibrin Clot Pathway (1269372); E2F Transcription Factor Network Pathway (137934); Endochondral Ossification Pathway (198812); FGF Signaling Pathway (137989)

This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

uPA: Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. Defects in PLAU are the cause of Quebec platelet disorder (QPD). QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; EC 3.4.21.73; Protease; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 10q22.2. Cellular Component: cell surface; extracellular region; extracellular space; focal adhesion; plasma membrane. Molecular Function: protein binding; serine-type endopeptidase activity. Biological Process: angiogenesis; blood coagulation; chemotaxis; embryo implantation; fibrinolysis; positive regulation of cell proliferation; positive regulation of smooth muscle cell migration; proteolysis; regulation of cell adhesion mediated by integrin; regulation of receptor activity; regulation of smooth muscle cell migration; response to activity; response to hyperoxia; signal transduction; skeletal muscle regeneration; smooth muscle cell migration; spermatogenesis. Disease: Alzheimer Disease; Quebec Platelet Disorder

0.05毫克

160美元

0.1毫克

235