产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
HLA class I (HLA-A) Rabbit Polyclonal
目录 :
MBS7600128
规格 :
0.1毫克
价格 :
320美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS7600128 图像 1
Immunohistochemistry of paraffin-embedded human esophagus using MBS7600128 (HLA class (HLA-A antibody) at dilution of 1:100
图像 2 :
MyBioSource MBS7600128 图像 2
HepG2 cells were subjected to SDS PAGE followed by western blot with MBS7600128(HLA class I(HLA-A antibody) at dilution of 1:1000
产品信息
目录号 :
MBS7600128
产品类型 :
抗体
产品全称 :
HLA class I (HLA-A) Rabbit Polyclonal
产品简称 :
[HLA class I (HLA-A)]
产品名称同义词 :
[人类白细胞抗原a, HLAA, HLA-A]
其他名称 :
[HLA class I histocompatibility antigen, A-1 alpha chain; HLA class I histocompatibility antigen, A-2 alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; major histocompatibility complex, class I, A; MHC class I antigen A*2]
产品基因名称 :
[HLA-A]
其他基因名称 :
[HLA-A; HLA-A; HLAA; Aw-33; Aw-74; HLA-A11; HLA-A33; HLA-DQB1; HLA-DRB1; HLAA]
UniProt数据库进入名 :
1A02_HUMAN
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
Human; Mouse; other species are not tested.
序列长度 :
365
特异性 :
Please decide specifity by homology.
纯度 :
>=95% as determined by SDS-PAGE. Immunogen Affinity Purified
形式 :
Liquid. PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
储存稳定性 :
-20°C for 24 months (Avoid repeated freeze / thaw cycles.)
检测过的应用 :
酶联免疫吸附测定, 免疫印迹, 免疫组化
应用笔记 :
WB: 1:500-1:2000。 IHC: 1:50-1:200
image1头 :
免疫组化免疫组化
image2头 :
免疫印迹免疫印迹
其它信息1 :
Immunogen: Major histocompatibility complex, class I, A. Calculated MW: 44 kDa
NCBI GI登录号 :
24797067
NCBI登录号 :
NP_002107.3
NCBI基因登录号 :
NM_002116.7
UniProt数据库登录号 :
P04439
NCBI信号通路 :
Adaptive Immune System Pathway (1269171); Allograft Rejection Pathway (920963); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (1269194); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (1269195); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533)
NCBI总结 :
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
HLAA: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family. Protein type: Membrane protein, integral; Immunoglobulin superfamily. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: cell surface; early endosome membrane; endoplasmic reticulum; Golgi apparatus; Golgi medial cisterna; Golgi membrane; integral to plasma membrane; membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane. Molecular Function: beta-2-microglobulin binding; peptide antigen binding; protein binding; receptor binding; T cell receptor binding; TAP binding. Biological Process: antibacterial humoral response; antigen processing and presentation; antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; defense response to Gram-positive bacterium; detection of bacterium; immune response; positive regulation of interferon-gamma production; positive regulation of T cell cytokine production; positive regulation of T cell mediated cytotoxicity; protection from natural killer cell mediated cytotoxicity; regulation of defense response to virus by virus; regulation of immune response; viral reproduction. Disease: Severe Cutaneous Adverse Reaction, Susceptibility To
尺寸1 :
0.1毫克
价格1 :
320美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。