产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
MME, CD10小鼠单克隆
目录 :
MBS7601465
规格 :
0.1毫克
价格 :
265美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS7601465 图像 1
Immunohistochemical of paraffin-embedded human renal cell carcinoma using MBS7601465(MME,CDIO antibody) at dilution of 1:100
图像 2 :
MyBioSource MBS7601465 图像 2
pig kidney tissue were subjected to SDS-PAGE followed by western blot with MBS7601465 (MME, CD 1 0 Antibody) at dilution of 1:1000
产品信息
目录号 :
MBS7601465
产品类型 :
抗体
产品全称 :
MME, CD10小鼠单克隆
产品简称 :
[MME, CD10]
产品名称同义词 :
[Atriopeptidase, CALLA, CD10, DKFZp686O16152, Enkephalinase, EPN, membrane metallo endopeptidase, MME, NEP, Neprilysin, Neutral endopeptidase, Neutral endopeptidase 24.11]
其他名称 :
[MME protein; Neprilysin; neprilysin; membrane metallo-endopeptidase; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD_antigen: CD10]
产品基因名称 :
[MME, CD10]
其他基因名称 :
[MME;MME;NEP;SFE;CD10;CALLA;EPN;CALLA;NEP;中性肽链内切酶;SFE]
UniProt数据库进入名 :
NEP_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG2a
宿主 :
小鼠
反应物种 :
Human, Pig. Other species are not tested.
序列长度 :
80
特异性 :
Please decide specifity by homology.
纯度 :
>=95% as determined by SDS-PAGE. Protein A+G purification
形式 :
液体
储存稳定性 :
Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)
检测过的应用 :
酶联免疫吸附测定, 免疫印迹, 免疫组化
应用笔记 :
免疫印迹1;500-1;5000。 免疫组化1;20-1;200
image1头 :
免疫组化
image2头 :
十二烷基磺酸钠-PAGE
其它信息1 :
Immunogen: Membrane metallo-endopeptidase. Calculated MW: 86kDa. Observed: 100kDa
其他信息2 :
Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3,
产品描述 :
MME is also named as neprilysin,CALLA,NEP,SFE,CD10 and belongs to the peptidase M13 family.It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium.CD10 has been considered a useful marker in the diagnosis of renal carcinomas, because of its expression in clear cell and papillary renal cell carcinomas and its absence in chromophobe renal cell carcinomas(PMID:15286660).This antibody is specific to MME.
NCBI GI登录号 :
76779253
NCBI登录号 :
AAI06071.1
NCBI信号通路 :
Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Metabolism Of Angiotensinogen To Angiotensins Pathway (1268749); Metabolism Of Proteins Pathway (1268677); Peptide Hormone Metabolism Pathway (1268746); Protein Digestion And Absorption Pathway (172847); Protein Digestion And Absorption Pathway (171868)
NCBI总结 :
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
CD10: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers. Inhibited in a dose dependent manner by opiorphin. Belongs to the peptidase M13 family. Protein type: EC 3.4.24.11; Protease; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3q25.2. Cellular Component: axon; brush border; cytoplasm; dendrite; focal adhesion; integral to membrane; integral to plasma membrane; plasma membrane; synapse; synaptic vesicle. Molecular Function: endopeptidase activity; exopeptidase activity; metalloendopeptidase activity; metallopeptidase activity; peptide binding; protein binding; zinc ion binding. Biological Process: angiotensin maturation; beta-amyloid metabolic process; creatinine metabolic process; kidney development; peptide metabolic process; proteolysis; sensory perception of pain. Disease: Membranous Nephropathy, Susceptibility To
尺寸1 :
0.1毫克
价格1 :
265美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。