抗体

PDGFD兔多克隆

MBS7602498

0.1毫克

290美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

PDGFD兔多克隆

[PDGFD]

[IEGF, Iris expressed growth factor, MSTP036, PDGF D, PDGFD, PDGFD receptor binding form, SCDGF B, SCDGFB, UNQ1899/PRO4345]

[platelet-derived growth factor D isoform 2; Platelet-derived growth factor D; platelet-derived growth factor D; platelet derived growth factor D; Iris-expressed growth factor; Spinal cord-derived growth factor B; SCDGF-B]

[PDGFD]

[PDGFD; PDGFD; IEGF; SCDGFB; MSTP036; SCDGF-B; IEGF; SCDGFB; PDGF-D; SCDGF-B; PDGFD latent form; PDGFD receptor-binding form]

PDGFD_HUMAN

多克隆

IgG

兔

人类, 小鼠, 大鼠

364

Human, Mouse, Rat; other species are not tested. Please decide the specificity by homology

>=95% as determined by SDS-PAGE. Immunogen Affinity Purified

液体

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

酶联免疫吸附测定(EIA), 免疫组化(免疫组化)

IHC: 1:20-1:200

Immunohistochemical

Immunogen: Platelet derived growth factor D

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix(By similarity).

15451921

NP_149126.1

NM_033135.3

43 kDa

Choline Metabolism In Cancer Pathway (1059539); Choline Metabolism In Cancer Pathway (1084232); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Gap Junction Pathway (83072); Gap Junction Pathway (483); Melanoma Pathway (83114); Melanoma Pathway (526); PI3K-Akt Signaling Pathway (692234)

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

PDGFD: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide; Oncoprotein. Chromosomal Location of Human Ortholog: 11q22.3. Cellular Component: endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi membrane. Molecular Function: growth factor activity; platelet-derived growth factor receptor binding. Biological Process: blood coagulation; multicellular organismal development; platelet-derived growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of fibroblast proliferation; positive regulation of MAP kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of smooth muscle cell proliferation; regulation of peptidyl-tyrosine phosphorylation

0.1毫克

290美元