SUMF1兔多克隆 | MyBioSource MBS7604620 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

SUMF1兔多克隆

MBS7604620

规格 :

0.1毫克

价格 :

290美元

克隆性 :

多克隆

宿主 :

兔

共轭标签 :

未共轭

反应物种 :

人类, 小鼠

应用 :

免疫印迹, 酶联免疫吸附测定, 酶免疫法

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图像

图像 1 :

mouse liver tissue were subjected to SDS PAGE followed by western blot with MBS7604620 (SUMF1 antibody) at dilution of 1:1000

产品信息

目录号 :

MBS7604620

产品类型 :

抗体

产品全称 :

SUMF1兔多克隆

产品简称 :

[SUMF1]

产品名称同义词 :

[AAPA3037, FGE, sulfatase modifying factor 1, SUMF1, UNQ3037/PRO9852]

其他名称 :

[sulfatase-modifying factor 1 isoform 3; Sulfatase-modifying factor 1; sulfatase-modifying factor 1; sulfatase modifying factor 1; C-alpha-formylglycine-generating enzyme 1]

产品基因名称 :

[SUMF1]

其他基因名称 :

[SUMF1;SUMF1;FGE;UNQ3037;AAPA3037;FGE]

UniProt数据库进入名 :

SUMF1_HUMAN

克隆性 :

多克隆

抗体亚型 :

IgG

宿主 :

兔

反应物种 :

人类, 小鼠

序列长度 :

354

特异性 :

Human, Mouse; other species are not tested. Please decide the specificity by homology.

纯度 :

>=95% as determined by SDS-PAGE. Immunogen Affinity Purified

形式 :

液体

储存稳定性 :

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

检测过的应用 :

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)

应用笔记 :

WB: 1:500-1:2000

image1头 :

免疫印迹

其它信息1 :

Immunogen: Sulfatase modifying factor 1

产品描述 :

Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE.

NCBI GI登录号 :

257470977

NCBI登录号 :

NP_001158147.1

NCBI基因登录号 :

NM_001164675.1

NCBI分子量 :

46 kDa

NCBI信号通路 :

Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway (1268702); Glycosphingolipid Metabolism Pathway (1270099); Lysosome Pathway (99052); Lysosome Pathway (96865); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Metabolism Of Proteins Pathway (1268677); Post-translational Protein Modification Pathway (1268701); Sphingolipid Metabolism Pathway (1270097); The Activation Of Arylsulfatases Pathway (1268709)

NCBI总结 :

This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

UniProt数据库总结 :

SUMF1: Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE. Defects in SUMF1 are the cause of multiple sulfatase deficiency (MSD). MSD is a clinically and biochemically heterogeneous disorder caused by the simultaneous impairment of all sulfatases, due to defective post-translational modification and activation. It combines features of individual sulfatase deficiencies such as metachromatic leukodystrophy, mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis, neurologic deterioration and developmental delay. Inheritance is autosomal recessive. Belongs to the sulfatase-modifying factor family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; Secreted; EC 1.8.99.-; Endoplasmic reticulum; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 3p26.1. Cellular Component: endoplasmic reticulum lumen. Molecular Function: metal ion binding; oxidoreductase activity; protein homodimerization activity. Biological Process: glycosphingolipid metabolic process; post-translational protein modification. Disease: Multiple Sulfatase Deficiency

尺寸1 :

0.1毫克

价格1 :

290美元

更多信息或购买 :

MyBioSource 产品网页

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