产品简要
公司名称 :
MyBioSource
产品类型 :
ELISA/assay
产品名称 :
人类溶酶体相关膜糖蛋白2酶联免疫吸附试剂盒
目录 :
MBS765274
规格 :
48-Strip-Wells
价格 :
295美元
更多信息或购买 :
产品信息
目录号 :
MBS765274
产品类型 :
酶联免疫吸附试剂盒
产品全称 :
人类溶酶体相关膜糖蛋白2酶联免疫吸附试剂盒
产品简称 :
溶酶体相关膜糖蛋白2
产品名称同义词 :
LAMP2/Lysosome-associated membrane glycoprotein 2/CD107 antigen-like family member B/LAMPB/LGP110/CD107b/CD107b antigen/LAMP-2/LAMPB
其他名称 :
lysosome-associated membrane glycoprotein 2 isoform A; Lysosome-associated membrane glycoprotein 2; lysosome-associated membrane glycoprotein 2; lysosomal associated membrane protein 2; CD107 antigen-like family member B; CD_antigen: CD107b
产品基因名称 :
LAMP2
其他基因名称 :
LAMP2; LAMP2; LAMPB; CD107b; LAMP-2; LGP110; LAMP-2; Lysosome-associated membrane protein 2
UniProt数据库进入名 :
LAMP2_HUMAN
反应物种 :
人类
序列长度 :
410
特异性 :
This assay has high sensitivity and excellent specificity for detection of Human LAMP2. No significant cross-reactivity or interference between Human LAMP2 and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the crossreactivity detection between Human LAMP2 and all the analogues, therefore, cross reaction may still exist.
储存稳定性 :
Store at 4 degree C if kit is to be used within 1 week. Stable for 6 months (if micro ELISA Plate, Lyophilized Standard and Concentrated Biotinylated Detection Protein stored at-20 degree C. Other components at 2-8 degree C). Stable for 12 months (if the entire kit is stored at-20 degree C).
其它信息1 :
Samples: Serum, plasma and other biological fluids. Assay Type: Sandwich. Detection Range: 0.313 -20ng/ml. Sensitivity: <0.188ng/ml
其他信息2 :
Intra-assay Precision: Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Human LAMP2 were tested 20 times on one plate, respectively. Intra-Assay: CV<8%. Inter-assay Precision: Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Human LAMP2 were tested on 3 different plates, 8 replicates in each plate. CV(%) = SD/meanX100. Inter-Assay: CV<10%
产品描述 :
Principle of the Assay This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-Human LAMP2antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human LAMP2 antibody was used as detection antibodies. The standards, test samples and biotin conjugated detection antibody were added to the wells subsequently, and wash with wash buffer. HRPStreptavidin was added and unbound conjugates were washed away with wash buffer. TMB substrates were used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The density of yellow is proportional to the Human LAMP2 amount of sample captured in plate. Read the O.D. absorbance at 450nm in a microplate reader, and then the concentration ofHuman LAMP2can be calculated.
NCBI GI登录号 :
4504957
NCBI登录号 :
NP_002285.1
NCBI基因登录号 :
NM_002294.2
NCBI分子量 :
45,170 Da
NCBI信号通路 :
Hemostasis Pathway (1269340); Lysosome Pathway (99052); Lysosome Pathway (96865); Phagosome Pathway (153910); Phagosome Pathway (153859); Platelet Activation, Signaling And Aggregation Pathway (1269350); Platelet Degranulation Pathway (1269367); Response To Elevated Platelet Cytosolic Ca2+ Pathway (1269365); Senescence And Autophagy Pathway (198780); Tuberculosis Pathway (213780)
NCBI总结 :
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
LAMP2: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: Xq24. Cellular Component: extracellular space; integral to membrane; late endosome; late endosome membrane; lysosomal lumen; lysosomal membrane; lysosome; membrane; phagocytic vesicle membrane; plasma membrane; platelet dense granule membrane. Molecular Function: enzyme binding; protein binding; protein domain specific binding. Biological Process: blood coagulation; platelet activation; platelet degranulation; protein import; protein stabilization; regulation of protein stability. Disease: Danon Disease
尺寸1 :
48-Strip-Wells
价格1 :
295美元
尺寸2 :
96-Strip-Wells
价格2 :
390
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。