抗体

ALK, CD246小鼠单克隆

MBS766542

0.1毫克

265美元

单克隆

小鼠

未共轭

免疫印迹, 酶联免疫吸附测定, 免疫组化

抗体

ALK, CD246小鼠单克隆

[ALK, CD246]

[ALK, ALK tyrosine kinase receptor, ALK,CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK]

[ALK tyrosine kinase receptor; ALK tyrosine kinase receptor; ALK tyrosine kinase receptor; anaplastic lymphoma receptor tyrosine kinase; Anaplastic lymphoma kinase; CD_antigen: CD246]

[ALK, CD246]

[ALK;ALK;CD246;NBLST3]

ALK_HUMAN

单克隆

IgG2a

小鼠

Human; other species are not tested.

1620

Please decide specifity by homology.

>=95% as determined by SDS-PAGE. Protein A+G purification

Liquid. PBS with 0.02% Sodium azide and 50% Glycerol pH 7.3

Store at -20°C for 24 months (Avoid repeated freeze/ thaw cycles)

酶联免疫吸附测定, 免疫组化, 免疫印迹

免疫印迹1:500-1:5000。 免疫组化1:20-1:200

免疫组化免疫组化

试验数据TD

Immunogen: Anaplastic lymphoma receptor tyrosine kinase. Calculated MW: 176 kDa

ALK, also named as CD246, is a receptor tyrosine kinase(RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM(Nucleophosmin)-ALK oncogenic fusion protein, resulting from the(2;5)(p23;q35)translocation that is frequently associated with anaplastic large-cell lymphoma(ALCL). TheEML4(echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer(NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC(PMID: 17625570).

29029632

NP_004295.2

NM_004304.4

Non-small Cell Lung Cancer Pathway (83119); Non-small Cell Lung Cancer Pathway (531)

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

ALK: a tyrosine kinase of the ALK family. Plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. Translocated and expressed as a fusion protein in anaplastic lymphoma. About one third of large-cell lymphomas are caused by a t(2;5)(p23;q35) translocation that fuses ALK to nucleophosmin (NPM1A). Other cases caused by fusions of ALK to moesin, non-muscle myosin heavy chain 9, clathrin heavy chain and other genes. Several fusions also seen in inflammatory myofibroblastic tumors, and expression has been briefly noted in a range of tumors. Protein type: Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Kinase, protein; Oncoprotein; TK group; Alk family. Chromosomal Location of Human Ortholog: 2p23. Cellular Component: integral to plasma membrane; intracellular; protein complex. Molecular Function: ATP binding; identical protein binding; NF-kappaB-inducing kinase activity; protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity. Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; cell proliferation; neuron development; peptidyl-tyrosine phosphorylation; phosphorylation; protein amino acid autophosphorylation; regulation of apoptosis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway. Disease: Neuroblastoma, Susceptibility To, 3

0.1毫克

265美元