抗体

EPO兔多克隆

MBS769047

0.1毫克

290美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

EPO兔多克隆

[EPO]

[EP, EPO, Epoetin, erythropoietin, MVCD2]

[erythropoietin; Erythropoietin; erythropoietin; erythropoietin; INN: Epoetin]

[EPO]

[EPO;EPO;EP;MVCD2]

EPO_HUMAN

多克隆

IgG

兔

Human, Mouse, Rat. Other species are not tested.

193

Please decide specifity by homology.

>=95% as determined by SDS-PAGE. Immunogen Affinity Purified

液体

Store at -20°C for 24 months (Avoid repeated freeze / thaw cycles.)

酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹), 免疫组化(免疫组化)

WB: 1:200-1:1000。 IHC:1:20-1:200

免疫组化(免疫组化)

试验数据

Immunogen: Erythropoietin. Calculated MW: 32 kDa. Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types.

62240997

NP_000790.2

NM_000799.2

Cellular Response To Hypoxia Pathway (1270415); Cellular Responses To Stress Pathway (1270414); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); EPO Receptor Signaling Pathway (198882); EPO Signaling Pathway (138051); HIF-1 Signaling Pathway (695200); HIF-1-alpha Transcription Factor Network Pathway (138045); HIF-2-alpha Transcription Factor Network Pathway (137956); Hematopoietic Cell Lineage Pathway (83078)

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]

EPO: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the EPO/TPO family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: cell surface; extracellular region; extracellular space. Molecular Function: erythropoietin receptor binding; hormone activity; protein binding; protein kinase activator activity. Biological Process: activation of protein kinase activity; acute-phase response; aging; apoptosis; blood circulation; embryo implantation; erythrocyte differentiation; erythrocyte maturation; hemoglobin biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; peptidyl-serine phosphorylation; positive regulation of activated T cell proliferation; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of Ras protein signal transduction; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat5 protein; response to axon injury; response to electrical stimulus; response to estrogen stimulus; response to hyperoxia; response to lipopolysaccharide; response to salt stress; response to testosterone stimulus; response to vitamin A; signal transduction. Disease: Microvascular Complications Of Diabetes, Susceptibility To, 2

0.1毫克

290美元