抗体

抗层粘连蛋白乙1抗体

MBS8202420

0.03毫升

155美元

多克隆

unidentified

未共轭

免疫印迹, 免疫组化

抗体

抗层粘连蛋白乙1抗体

[层粘连蛋白乙1]

[层粘连蛋白亚单位乙1;层粘连蛋白B1链;层粘连蛋白1亚单位乙;层粘连蛋白10亚单位乙;层粘连蛋白12亚单位乙;层粘连蛋白2亚单位乙;层粘连蛋白6亚单位乙;层粘连蛋白8亚单位乙]

[层粘连蛋白亚单位乙1;层粘连蛋白亚单位乙1;层粘连蛋白亚单位乙1;层粘连蛋白, 乙1;层粘连蛋白B1链;层粘连蛋白1亚单位乙;层粘连蛋白10亚单位乙;层粘连蛋白12亚单位乙;层粘连蛋白2亚单位乙;层粘连蛋白6亚单位乙;层粘连蛋白8亚单位乙]

[LAMB1]

[LAMB1;LAMB1;CLM;LIS5]

LAMB1_HUMAN

多克隆

未知

人类

1786

Recognizes endogenous levels of Laminin beta 1 protein.

The antibody was purified by immunogen affinity chromatography.

液体0.42% 钾磷酸盐, 0.87% 氯化钠, pH值7.3, 30% 甘油, 和0.01% 叠氮化钠

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

免疫印迹(免疫印迹), 免疫组化(免疫组化)

免疫印迹(1/500 - 1/1000), 免疫组化(1/100 - 1/200)

免疫印迹(免疫印迹)

免疫组化(免疫组化)

Source: Rabbit. Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Laminin beta 1. The exact sequence is proprietary.

兔多克隆抗体层粘连蛋白乙1

167614504

NP_002282.2

NM_002291.2

P07942

Alpha6-Beta4 Integrin Signaling Pathway (198807); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Axon Guidance Pathway (1270303); Degradation Of The Extracellular Matrix Pathway (1270257); Developmental Biology Pathway (1270302); ECM Proteoglycans Pathway (1270256); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (1270244)

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]

LAMB1: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: extracellular matrix; extracellular space; laminin-8 complex; laminin-1 complex; laminin-2 complex; perinuclear region of cytoplasm; laminin-10 complex; extracellular region; basement membrane. Molecular Function: integrin binding; enzyme binding; extracellular matrix structural constituent; structural molecule activity; glycosphingolipid binding. Biological Process: odontogenesis; axon guidance; extracellular matrix disassembly; extracellular matrix organization and biogenesis; neuronal-glial interaction involved in cerebral cortex radial glia guided migration; negative regulation of cell adhesion; cell adhesion; neurite development; positive regulation of epithelial cell proliferation; embryo implantation; positive regulation of cell migration. Disease: Lissencephaly 5

0.03毫升

155美元

0.1毫升

220

0.2毫升

295