产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗组织蛋白酶A 32k抗体
目录 :
MBS820402
规格 :
0.03毫升
价格 :
155美元
克隆性 :
多克隆
宿主 :
unidentified
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS820402 图像 1
Western blot analysis of Cathepsin A 32k expression in HepG2 (A), mouse kidney (B), rat liver (C) whole cell lysates.
产品信息
目录号 :
MBS820402
产品类型 :
抗体
产品全称 :
抗组织蛋白酶A 32k抗体
产品简称 :
[组织蛋白酶A 32k]
产品名称同义词 :
[PPGB; Lysosomal protective protein; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A; Protective protein cathepsin A; PPCA; Protective protein for beta-galactosidase]
其他名称 :
[lysosomal protective protein isoform a; Lysosomal protective protein; lysosomal protective protein; deamidase; urinary kininase; carboxypeptidase C; carboxypeptidase L; carboxypeptidase-L; beta-galactosidase 2; lysosomal carboxypeptidase A; protective protein cathepsin A; carboxypeptidase Y-like kininase; beta-galactosidase protective protein; cathepsin A; Carboxypeptidase C; Carboxypeptidase L; Cathepsin A; Protective protein cathepsin A; PPCA; Protective protein for beta-galactosidaseCleaved into the following 2 chains:Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain]
产品基因名称 :
[CTSA]
其他基因名称 :
[CTSA;CTSA;GSL;GLB2;NGBE;PPCA;PPGB;PPGB;PPCA]
UniProt数据库进入名 :
PPGB_HUMAN
克隆性 :
多克隆
宿主 :
未知
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
498
特异性 :
Recognizes endogenous levels of Cathepsin A 32k protein.
纯度 :
The antibody was purified by immunogen affinity chromatography.
形式 :
液体0.42% 钾磷酸盐, 0.87% 氯化钠, pH值7.3, 30% 甘油, 和0.01% 叠氮化钠
储存稳定性 :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹)
应用笔记 :
免疫印迹(1/500 - 1/1000)
image1头 :
免疫印迹(免疫印迹)
其他信息2 :
Source: Rabbit. Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Cathepsin A 32k. The exact sequence is proprietary.
产品描述 :
兔多克隆抗体组织蛋白酶A 32k
NCBI GI登录号 :
119395729
NCBI登录号 :
NP_000299.2
NCBI基因登录号 :
NM_000308.2
UniProt数据库登录号 :
P10619
NCBI分子量 :
52,489 Da
NCBI信号通路 :
Adaptive Immune System Pathway (366160); Asparagine N-linked Glycosylation Pathway (161013); Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway (161014); Glycosphingolipid Metabolism Pathway (530751); Immune System Pathway (106386); Lysosome Pathway (99052); Lysosome Pathway (96865); MHC Class II Antigen Presentation Pathway (645290); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976)
NCBI总结 :
This gene encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
CTSA: Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins. Defects in CTSA are the cause of galactosialidosis (GSL). A lysosomal storage disease associated with a combined deficiency of beta-galactosidase and neuraminidase, secondary to a defect in cathepsin A. All patients have clinical manifestations typical of a lysosomal disorder, such as coarse facies, cherry red spots, vertebral changes, foam cells in the bone marrow, and vacuolated lymphocytes. Three phenotypic subtypes are recognized. The early infantile form is associated with fetal hydrops, edema, ascites, visceromegaly, skeletal dysplasia, and early death. The late infantile type is characterized by hepatosplenomegaly, growth retardation, cardiac involvement, and a normal or mildly affected mental state. The juvenile/adult form is characterized by myoclonus, ataxia, angiokeratoma, mental retardation, neurologic deterioration, absence of visceromegaly, and long survival. Belongs to the peptidase S10 family. Protein type: Endoplasmic reticulum; EC 3.4.16.5; Protease; Mitochondrial. Chromosomal Location of Human Ortholog: 20q13.1. Cellular Component: nucleoplasm; lysosomal lumen; membrane; intracellular membrane-bound organelle; lysosome; endoplasmic reticulum. Molecular Function: serine carboxypeptidase activity; carboxypeptidase activity; enzyme activator activity. Biological Process: positive regulation of catalytic activity; intracellular protein transport; cellular protein metabolic process; sphingolipid metabolic process; dolichol-linked oligosaccharide biosynthetic process; protein amino acid N-linked glycosylation via asparagine; glycosphingolipid metabolic process; proteolysis; post-translational protein modification. Disease: Galactosialidosis
尺寸1 :
0.03毫升
价格1 :
155美元
尺寸2 :
0.1毫升
价格2 :
220
size3 :
0.2毫升
价格3 :
295
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。