产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗GSK3乙抗体
目录 :
MBS8207657
规格 :
0.03毫升
价格 :
155美元
克隆性 :
多克隆
宿主 :
unidentified
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, , 斑马鱼
应用 :
免疫印迹, 免疫组化, 免疫沉淀
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS8207657 图像 1
Western blot analysis of GSK3 beta expression in MDA-MB-435 (A), Raw264.7 (B) whole cell lysates.
图像 2 :
MyBioSource MBS8207657 图像 2
Immunohistochemical analysis of GSK3 beta staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
产品信息
目录号 :
MBS8207657
产品类型 :
抗体
产品全称 :
抗GSK3乙抗体
产品简称 :
[GSK3乙]
产品名称同义词 :
[糖原合酶激酶3乙;GSK-3乙;丝氨酸/苏氨酸蛋白激酶GSK3B]
其他名称 :
[glycogen synthase kinase-3 beta isoform 2; Glycogen synthase kinase-3 beta; glycogen synthase kinase-3 beta; glycogen synthase kinase 3 beta; Serine/threonine-protein kinase GSK3B (EC:2.7.11.1)]
产品基因名称 :
[GSK3B]
其他基因名称 :
[GSK3B;GSK3B;GSK-3乙]
UniProt数据库进入名 :
GSK3B_HUMAN
克隆性 :
多克隆
宿主 :
未知
反应物种 :
人类, 小鼠, 大鼠, 牛, 猪, 羊, 斑马鱼
序列长度 :
433
特异性 :
Recognizes endogenous levels of GSK3 beta protein.
纯度 :
The antibody was purified by immunogen affinity chromatography.
形式 :
液体0.42% 钾磷酸盐, 0.87% 氯化钠, pH值7.3, 30% 甘油, 和0.01% 叠氮化钠
储存稳定性 :
Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
检测过的应用 :
免疫印迹, IH, 免疫沉淀
应用笔记 :
免疫印迹(1/500 - 1/1000)。 IH(1/100 - 1/200)。 免疫沉淀(1/10 - 1/100)
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
其它信息1 :
. Source: Rabbit. Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GSK3 beta. The exact sequence is proprietary.
产品描述 :
兔多克隆抗体GSK3乙
NCBI GI登录号 :
225903437
NCBI登录号 :
NP_001139628.1
NCBI基因登录号 :
NM_001146156.1
UniProt数据库登录号 :
P49841
NCBI信号通路 :
AKT Phosphorylates Targets In The Cytosol Pathway (1269189); AMER1 Mutants Destabilize The Destruction Complex Pathway (1268913); APC Truncation Mutants Have Impaired AXIN Binding Pathway (1268909); AXIN Missense Mutants Destabilize The Destruction Complex Pathway (1268912); AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway (1268910); Adaptive Immune System Pathway (1269171); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Androgen Receptor Signaling Pathway (198806)
NCBI总结 :
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt数据库总结 :
GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation. Protein type: Kinase, protein; Protein kinase, CMGC; EC 2.7.11.26; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CMGC group; GSK family; GSK subfamily. Chromosomal Location of Human Ortholog: 3q13.3. Cellular Component: nucleoplasm; centrosome; growth cone; cell soma; perinuclear region of cytoplasm; cytoplasm; plasma membrane; dendritic spine; dendritic shaft; beta-catenin destruction complex; nucleus; cytosol; ribonucleoprotein complex; lipid raft. Molecular Function: p53 binding; beta-catenin binding; protein kinase binding; integrin binding; protein serine/threonine kinase activity; NF-kappaB binding; ionotropic glutamate receptor binding; protein binding; ubiquitin protein ligase binding; tau-protein kinase activity; kinase activity; tau protein binding; ATP binding. Biological Process: circadian rhythm; glycogen metabolic process; fat cell differentiation; axon guidance; negative regulation of MAP kinase activity; re-entry into mitotic cell cycle; genetic imprinting; positive regulation of protein binding; nerve growth factor receptor signaling pathway; response to lithium ion; protein amino acid autophosphorylation; positive regulation of axon extension; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; positive regulation of protein export from nucleus; protein export from nucleus; positive regulation of cell-matrix adhesion; negative regulation of protein binding; ER overload response; myoblast fusion; negative regulation of glycogen biosynthetic process; response to drug; epidermal growth factor receptor signaling pathway; regulation of microtubule-based process; cell migration; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; hippocampus development; negative regulation of dendrite morphogenesis; negative regulation of NFAT protein import into nucleus; positive regulation of peptidyl-serine phosphorylation; negative regulation of neuron maturation; organ morphogenesis; peptidyl-serine phosphorylation; positive regulation of protein complex assembly; establishment of cell polarity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; epithelial to mesenchymal transition; innate immune response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein complex assembly; negative regulation of apoptosis; regulation of neuronal synaptic plasticity
尺寸1 :
0.03毫升
价格1 :
155美元
尺寸2 :
0.1毫升
价格2 :
220
size3 :
0.2毫升
价格3 :
295
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。