产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗胶原2甲1抗体
目录 :
MBS8210940
规格 :
0.03毫升
价格 :
155美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 狗, 牛
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
图像
图像 1 :
Western blot analysis of Collagen 2 alpha 1 expression in MCF7 (A) whole cell lysates.
图像 2 :
Immunohistochemical analysis of Collagen 2 alpha 1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
产品信息
目录号 :
MBS8210940
产品类型 :
抗体
产品全称 :
抗胶原2甲1抗体
产品简称 :
[胶原2甲1]
产品名称同义词 :
[胶原甲1(II)链;甲1Ⅱ型胶原]
其他名称 :
[collagen alpha-1(II) chain isoform 1; Collagen alpha-1(II) chain; collagen alpha-1(II) chain; collagen, type II, alpha 1; Alpha-1 type II collagen]
产品基因名称 :
[COL2A1]
其他基因名称 :
[COL2A1;COL2A1;AOM;ANFH;SEDC;STL1;COL11A3]
UniProt数据库进入名 :
CO2A1_HUMAN
克隆性 :
多克隆
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠, 牛, 狗, 猪, 兔
序列长度 :
268
特异性 :
Recognizes endogenous levels of Collagen 2 alpha 1 protein.
纯度 :
The antibody was purified by immunogen affinity chromatography.
形式 :
液体0.42% 钾磷酸盐, 0.87% 氯化钠, pH值7.3, 30% 甘油, 和0.01% 叠氮化钠
储存稳定性 :
Ships on blue ice. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
免疫印迹(1/500 - 1/1000)。 免疫组化(1/100 - 1/200)
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
其它信息1 :
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Collagen 2 alpha 1. The exact sequence is proprietary.
产品描述 :
兔多克隆抗体胶原2甲1
NCBI GI登录号 :
111118976
NCBI登录号 :
NP_001835.3
NCBI基因登录号 :
NM_001844.4
UniProt数据库登录号 :
P02458
NCBI信号通路 :
Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (1270247); Collagen Biosynthesis And Modifying Enzymes Pathway (1270246); Collagen Formation Pathway (1270245); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Endochondral Ossification Pathway (198812); Extracellular Matrix Organization Pathway (1270244); Focal Adhesion Pathway (198795)
NCBI总结 :
This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
COL2A1: the alpha-1 chain of type II collagen, an extra-cellular matrix protein found in cartilage and the vitreous humor of the eye. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Chondrocalcin is the calcium binding C-propeptide of this collagen molecule. Defects in this protein are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. There are two transcripts identified for this gene. Belongs to the fibrillar collagen family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted; Extracellular matrix. Chromosomal Location of Human Ortholog: 12q13.11. Cellular Component: extracellular matrix; extracellular space; endoplasmic reticulum lumen; collagen type II; extracellular region; basement membrane. Molecular Function: identical protein binding; metal ion binding; platelet-derived growth factor binding; extracellular matrix structural constituent conferring tensile strength. Biological Process: heart morphogenesis; proteoglycan metabolic process; axon guidance; extracellular matrix organization and biogenesis; inner ear morphogenesis; central nervous system development; collagen fibril organization; palate development; notochord development; collagen catabolic process; extracellular matrix disassembly; limb bud formation; sensory perception of sound; visual perception; regulation of gene expression; cartilage development; tissue homeostasis; chondrocyte differentiation; skeletal development; endochondral ossification; cartilage condensation. Disease: Platyspondylic Lethal Skeletal Dysplasia, Torrance Type; Achondrogenesis, Type Ii; Kniest Dysplasia; Otospondylomegaepiphyseal Dysplasia; Spondyloepimetaphyseal Dysplasia, Strudwick Type; Spondyloepiphyseal Dysplasia Congenita; Avascular Necrosis Of Femoral Head, Primary; Legg-calve-perthes Disease; Spondyloperipheral Dysplasia; Epiphyseal Dysplasia, Multiple, With Myopia And Conductive Deafness; Osteoarthritis With Mild Chondrodysplasia; Stickler Syndrome, Type I; Czech Dysplasia; Stickler Syndrome, Type I, Nonsyndromic Ocular
尺寸1 :
0.03毫升
价格1 :
155美元
尺寸2 :
0.1毫升
价格2 :
220
size3 :
0.2毫升
价格3 :
295
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。