抗体

Anti-PKC delta (pY52) Antibody

MBS821123

0.03毫升

165美元

多克隆

unidentified

未共轭

人类, 小鼠, 大鼠, 狗, 鸡, 牛

抗体

Anti-PKC delta (pY52) Antibody

[PKC delta (pY52)]

[Protein kinase C delta type; Tyrosine-protein kinase PRKCD; nPKC-delta]

[protein kinase C delta type; Protein kinase C delta type; protein kinase C delta type; protein kinase C delta VIII; tyrosine-protein kinase PRKCD; protein kinase C, delta; Tyrosine-protein kinase PRKCD (EC:2.7.10.2); nPKC-deltaCleaved into the following 2 chains:Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunitAlternative name(s):Sphingosine-dependent protein kinase-1; SDK1]

[PRKCD]

[PRKCD; PRKCD; MAY1; PKCD; ALPS3; CVID9; nPKC-delta; SDK1]

KPCD_HUMAN

多克隆

未知

Human, Mouse, Rat, Bovine, Chicken, Dog, Monkey, Pig, Rabbit

676

Recognizes endogenous levels of PKC delta (pY52) protein.

The antibody was purified by immunogen affinity chromatography.

液体0.42% 钾磷酸盐, 0.87% 氯化钠, pH值7.3, 30% 甘油, 和0.01% 叠氮化钠

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

免疫印迹(免疫印迹)

免疫印迹(1/500 - 1/1000)

免疫印迹(免疫印迹)

Source: Rabbit

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PKC delta. The exact sequence is proprietary.

Rabbit polyclonal antibody to PKC delta (pY52)

31377782

NP_006245.2

NM_006254.3

Q05655

AGE/RAGE Pathway (698754); Alpha-synuclein Signaling Pathway (137913); Alpha6-Beta4 Integrin Signaling Pathway (198807); Apoptosis Pathway (105648); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); B Cell Receptor Signaling Pathway (198909); BDNF Signaling Pathway (712093); Ca-dependent Events Pathway (106497); CaM Pathway (106468)

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

PKCD: an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities. Protein type: Protein kinase, AGC; EC 2.7.11.13; Nuclear receptor co-regulator; Tumor suppressor; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; AGC group; PKC family; Delta subfamily. Chromosomal Location of Human Ortholog: 3p21.31. Cellular Component: nucleoplasm; nuclear matrix; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; intercellular junction; cytosol; nucleus. Molecular Function: calcium-independent protein kinase C activity; protein serine/threonine kinase activity; protein binding; enzyme binding; protein kinase C activity; insulin receptor substrate binding; metal ion binding; enzyme activator activity; non-membrane spanning protein tyrosine kinase activity; ATP binding. Biological Process: B cell proliferation; negative regulation of MAP kinase activity; peptidyl-tyrosine phosphorylation; interleukin-12 production; nerve growth factor receptor signaling pathway; apoptosis; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of protein amino acid dephosphorylation; negative regulation of filopodium formation; positive regulation of superoxide release; regulation of receptor activity; negative regulation of protein binding; cell structure disassembly during apoptosis; epidermal growth factor receptor signaling pathway; platelet activation; negative regulation of peptidyl-tyrosine phosphorylation; fibroblast growth factor receptor signaling pathway; protein stabilization; neutrophil activation; negative regulation of actin filament polymerization; cytokine and chemokine mediated signaling pathway; peptidyl-threonine phosphorylation; cell cycle; phospholipase C activation; negative regulation of inflammatory response; defense response to bacterium; interleukin-10 production; innate immune response; gene expression; immunoglobulin mediated immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway; induction of apoptosis by oxidative stress. Disease: Autoimmune Lymphoproliferative Syndrome, Type Iii

0.03毫升

165美元

0.1毫升

245

0.2毫升

350