抗体

抗c-SRC(pY529)抗体

MBS821259

0.03毫升

165美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠, 鸡, 斑马鱼

免疫印迹, 免疫组化

抗体

抗c-SRC(pY529)抗体

[c-SRC(pY529)]

[SRC1; Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pp60c-src; p60-Src]

[proto-oncogene tyrosine-protein kinase Src; Proto-oncogene tyrosine-protein kinase Src; proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; SRC proto-oncogene, non-receptor tyrosine kinase; Proto-oncogene c-Src; pp60c-src; p60-Src]

[SRC]

[SRC; SRC; ASV; SRC1; c-SRC; p60-Src; SRC1; p60-Src]

SRC_HUMAN

多克隆

兔

人类, 小鼠, 大鼠, 鸡, 斑马鱼

536

Recognizes endogenous levels of c-SRC (pY529) protein.

The antibody was purified by immunogen affinity chromatography.

液体0.42% 钾磷酸盐, 0.87% 氯化钠, pH值7.3, 30% 甘油, 和0.01% 叠氮化钠

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

免疫印迹(免疫印迹), 免疫组化(免疫组化)

免疫印迹(1/500 - 1/1000), IH(1/100 - 1/200)

免疫印迹(免疫印迹)

免疫组化(免疫组化)

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human c-SRC. The exact sequence is proprietary.

兔多克隆抗体c-SRC(pY529)

4885609

NP_005408.1

NM_005417.4

P12931

60,589 Da

ADP Signalling Through P2Y Purinoceptor 1 Pathway (161061); AGE/RAGE Pathway (698754); Adaptive Immune System Pathway (366160); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); AhR Pathway (755436); Alpha-synuclein Signaling Pathway (137913); Alpha6-Beta4 Integrin Signaling Pathway (198807); Androgen Receptor Signaling Pathway (198806); Angiogenesis Pathway (198772)

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Src: proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme; phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme. Two alternatively spliced isoforms have been described. Protein type: EC 2.7.10.2; Protein kinase, TK; Oncoprotein; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Src family. Chromosomal Location of Human Ortholog: 20q12-q13. Cellular Component: neuron projection; mitochondrion; lysosome; postsynaptic density; actin filament; caveola; cytosol; extrinsic to internal side of plasma membrane; perinuclear region of cytoplasm; cytoplasm; late endosome; mitochondrial inner membrane; plasma membrane; nucleus. Molecular Function: protein C-terminus binding; ephrin receptor binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; insulin receptor binding; protein kinase activity; integrin binding; protein binding; enzyme binding; SH3/SH2 adaptor activity; protein kinase C binding; protein-tyrosine kinase activity; heme binding; estrogen receptor binding; kinase activity; SH2 domain binding; ATP binding; receptor binding; hormone receptor binding. Biological Process: oogenesis; regulation of estrogen receptor signaling pathway; central nervous system development; positive regulation of cyclin-dependent protein kinase activity; estrogen receptor signaling pathway; progesterone receptor signaling pathway; nerve growth factor receptor signaling pathway; viral reproduction; regulation of cell cycle; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; uterus development; negative regulation of mitochondrial depolarization; negative regulation of protein homooligomerization; positive regulation of MAP kinase activity; cell-cell adhesion; transforming growth factor beta receptor signaling pathway; cell adhesion; response to electrical stimulus; bone resorption; response to drug; platelet activation; fibroblast growth factor receptor signaling pathway; response to virus; activation of protein kinase B; transcytosis; positive regulation of integrin activation; positive regulation of protein amino acid autophosphorylation; cellular response to insulin stimulus; response to mechanical stimulus; T cell costimulation; regulation of vascular permeability; negative regulation of transcription, DNA-dependent; leukocyte migration; negative regulation of apoptosis; axon guidance; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; platelet-derived growth factor receptor signaling pathway; negative regulation of caspase activity; positive regulation of smooth muscle cell migration; signal transduction; regulation of cell-cell adhesion; forebrain development; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; response to nutrient levels; regulation of bone resorption; negative regulation of focal adhesion formation; positive regulation of phosphoinositide 3-kinase activity; signal complex assembly; response to mineralocorticoid stimulus; cell cycle; regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; cell proliferation; peptidyl-serine phosphorylation; response to hydrogen peroxide; regulation of protein binding; Ras protein signal transduction; stress fiber formation; innate immune response; positive regulation of insulin receptor signaling pathway; response to acidity; vascular endothelial growth factor receptor signaling pathway; blood coagulation; positive regulation of cytokine secretion

0.03毫升

165美元

0.1毫升

245

0.2毫升

350