产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗神经纤毛蛋白1抗体
目录 :
MBS821583
规格 :
0.03毫升
价格 :
155美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 大鼠
应用 :
免疫印迹
更多信息或购买 :
图像
图像 1 :
Western blot analysis of Neuropilin 1 expression in HUVEC (A), MDAMB231 (B), COS7 (C) whole cell lysates.
图像 2 :
产品信息
目录号 :
MBS821583
产品类型 :
抗体
产品全称 :
抗神经纤毛蛋白1抗体
产品简称 :
[神经纤毛蛋白1]
产品名称同义词 :
[NRP;VEGF165R;神经纤毛蛋白1;血管内皮细胞生长因子165受体;CD304]
其他名称 :
[neuropilin-1 isoform b; Neuropilin-1; neuropilin-1; transmembrane receptor; vascular endothelial cell growth factor 165 receptor; neuropilin 1; Vascular endothelial cell growth factor 165 receptor; CD_antigen: CD304]
产品基因名称 :
[NRP1]
其他基因名称 :
[NRP1;NRP1;NP1;NRP;BDCA4;CD304;VEGF165R;NRP;VEGF165R]
UniProt数据库进入名 :
NRP1_HUMAN
克隆性 :
多克隆
宿主 :
兔
反应物种 :
Human, Rat, Monkey
序列长度 :
644
特异性 :
Recognizes endogenous levels of Neuropilin 1 protein.
纯度 :
The antibody was purified by immunogen affinity chromatography.
形式 :
液体0.42% 钾磷酸盐, 0.87% 氯化钠, pH值7.3, 30% 甘油, 和0.01% 叠氮化钠
储存稳定性 :
Shipped at 4°C. Upon delivery aliquot and store at -20° C for one year. Avoid freeze/thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹)
应用笔记 :
免疫印迹(1/500 - 1/1000)
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
其他信息2 :
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Neuropilin 1. The exact sequence is proprietary.
产品描述 :
兔多克隆抗体神经纤毛蛋白1
NCBI GI登录号 :
66912178
NCBI登录号 :
NP_001019799.1
NCBI基因登录号 :
NM_001024628.2
UniProt数据库登录号 :
O14786
NCBI信号通路 :
Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); CHL1 Interactions Pathway (161007); CRMPs In Sema3A Signaling Pathway (119525); Developmental Biology Pathway (477129); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); L1CAM Interactions Pathway (161003); Neurophilin Interactions With VEGF And VEGFR Pathway (106509)
NCBI总结 :
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
UniProt数据库总结 :
NRP1: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. Homodimer, and heterodimer with NRP2. Interacts with FER. Binds PLXNB1. The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules. Belongs to the neuropilin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 10p12. Cellular Component: extracellular space; cell surface; focal adhesion; early endosome; integral to membrane; cytosol; growth cone; cell soma; axon; plasma membrane; neurofilament; cytoplasmic vesicle; receptor complex. Molecular Function: heparin binding; vascular endothelial growth factor receptor activity; protein binding; semaphorin receptor activity; growth factor binding; cytokine binding; metal ion binding; coreceptor activity. Biological Process: facial nerve structural organization; axon guidance; neuron migration; vestibulocochlear nerve structural organization; platelet-derived growth factor receptor signaling pathway; signal transduction; negative regulation of axon extension involved in axon guidance; positive regulation of smooth muscle cell migration; gonadotrophin-releasing hormone neuronal migration to the hypothalamus; cell-cell signaling; positive chemotaxis; branchiomotor neuron axon guidance; dendrite development; response to wounding; negative regulation of neuron apoptosis; angiogenesis; trigeminal nerve structural organization; axonal fasciculation; hepatocyte growth factor receptor signaling pathway; patterning of blood vessels; axon extension involved in axon guidance; organ morphogenesis; positive regulation of peptidyl-tyrosine phosphorylation; cell migration during sprouting angiogenesis; otic placode formation; positive regulation of axon extension involved in axon guidance; artery morphogenesis; nerve development; positive regulation of endothelial cell proliferation; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; retinal ganglion cell axon guidance
尺寸1 :
0.03毫升
价格1 :
155美元
尺寸2 :
0.1毫升
价格2 :
220
size3 :
0.2毫升
价格3 :
295
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。