产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗水闸蛋白1抗体
目录 :
MBS821600
规格 :
0.03毫升
价格 :
155美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 狗, 牛
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
图像
图像 1 :
Western blot analysis of Claudin 1 expression in HeLa (A), HepG2 (B), mouse kideney (C), rat kidney (D) whole cell lysates.
图像 2 :
Immunohistochemical analysis of Claudin 1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
产品信息
目录号 :
MBS821600
产品类型 :
抗体
产品全称 :
抗水闸蛋白1抗体
产品简称 :
[水闸蛋白1]
产品名称同义词 :
[CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein]
其他名称 :
[claudin-1; Claudin-1; claudin-1; senescence-associated epithelial membrane protein 1; claudin 1; Senescence-associated epithelial membrane protein]
产品基因名称 :
[CLDN1]
其他基因名称 :
[CLDN1;CLDN1;CLD1;SEMP1;ILVASC;CLD1;SEMP1]
UniProt数据库进入名 :
CLD1_HUMAN
克隆性 :
多克隆
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠, 牛, 狗, 羊
序列长度 :
211
特异性 :
Recognizes endogenous levels of Claudin 1 protein.
纯度 :
The antibody was purified by immunogen affinity chromatography.
形式 :
液体0.42% 钾磷酸盐, 0.87% 氯化钠, pH值7.3, 30% 甘油, 和0.01% 叠氮化钠
储存稳定性 :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
免疫印迹(1/500 - 1/1000), 免疫组化(1/100 - 1/200)
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
其他信息2 :
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Claudin 1. The exact sequence is proprietary.
产品描述 :
兔多克隆抗体水闸蛋白1
NCBI GI登录号 :
10863887
NCBI登录号 :
NP_066924.1
NCBI基因登录号 :
NM_021101.4
UniProt数据库登录号 :
O95832
NCBI信号通路 :
Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132); Cell-cell Junction Organization Pathway (119532); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494); Nectin Adhesion Pathway (138054)
NCBI总结 :
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
Claudin-1: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Acts as a co- receptor for HCV entry into hepatic cells. Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL. May interact with HCV E1 and E2 proteins. Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. Belongs to the claudin family. Protein type: Membrane protein, multi-pass; Cytoskeletal; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3q28-q29. Cellular Component: tight junction; integral to plasma membrane; apical plasma membrane; integral to membrane; lateral plasma membrane. Molecular Function: identical protein binding; protein binding; structural molecule activity. Biological Process: intercellular junction assembly and maintenance; viral reproduction; cell adhesion; calcium-independent cell-cell adhesion. Disease: Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis
尺寸1 :
0.03毫升
价格1 :
155美元
尺寸2 :
0.1毫升
价格2 :
220
size3 :
0.2毫升
价格3 :
295
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。