产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗信号传导子及转录激活子1抗体
目录 :
MBS8219182
规格 :
0.03毫升
价格 :
155美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 狗, 鸡, 牛
应用 :
免疫印迹, 免疫组化, 免疫沉淀
更多信息或购买 :
图像
图像 1 :
Western blot analysis of STAT1 expression in HeLa (A), NIH3T3 (B), PC12 (C) whole cell lysates.
图像 2 :
Immunohistochemical analysis of STAT1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
产品信息
目录号 :
MBS8219182
产品类型 :
抗体
产品全称 :
抗信号传导子及转录激活子1抗体
产品简称 :
[信号传导子及转录激活子1]
产品名称同义词 :
[Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84]
其他名称 :
[signal transducer and activator of transcription 1-alpha/beta isoform alpha; Signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription 1, 91kDa; Transcription factor ISGF-3 components p91/p84]
产品基因名称 :
[信号传导子及转录激活子1]
其他基因名称 :
[信号传导子及转录激活子1;信号传导子及转录激活子1;CANDF7;IMD31A;IMD31B;IMD31C;ISGF-3;STAT91]
UniProt数据库进入名 :
STAT1_HUMAN
克隆性 :
多克隆
宿主 :
兔
反应物种 :
Human, Mouse, Rat, Bovine, Chicken, Dog, Monkey, Porcine
序列长度 :
750
特异性 :
Recognizes endogenous levels of STAT1 protein.
纯度 :
The antibody was purified by immunogen affinity chromatography.
形式 :
液体0.42% 钾磷酸盐, 0.87% 氯化钠, pH值7.3, 30% 甘油, 和0.01% 叠氮化钠
储存稳定性 :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫沉淀(免疫沉淀)
应用笔记 :
免疫印迹(1/500 - 1/1000), 免疫组化(1/100 - 1/200), 免疫沉淀(1/10 - 1/100)
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
其它信息1 :
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human STAT1. The exact sequence is proprietary.
产品描述 :
兔多克隆抗体信号传导子及转录激活子1
NCBI GI登录号 :
6274552
NCBI登录号 :
NP_009330.1
NCBI基因登录号 :
NM_007315.3
UniProt数据库登录号 :
P42224
NCBI分子量 :
83,043 Da
NCBI信号通路 :
AGE/RAGE Pathway (698754); Adipogenesis Pathway (198832); Antiviral Mechanism By IFN-stimulated Genes Pathway (1269316); B Cell Receptor Signaling Pathway (198909); BDNF Signaling Pathway (712093); CXCR4-mediated Signaling Events Pathway (137910); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Cytokine Signaling In Immune System Pathway (1269310); Disease Pathway (1268854)
NCBI总结 :
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
STAT1: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 2q32.2. Cellular Component: nucleoplasm; axon; dendrite; cytoplasm; nuclear chromatin; nucleolus; nucleus; cytosol. Molecular Function: identical protein binding; signal transducer activity; protein binding; protein homodimerization activity; enzyme binding; double-stranded DNA binding; tumor necrosis factor receptor binding; transcription factor activity; CCR5 chemokine receptor binding. Biological Process: transcription from RNA polymerase II promoter; response to peptide hormone stimulus; response to cAMP; viral reproduction; apoptosis; blood circulation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; response to exogenous dsRNA; tumor necrosis factor-mediated signaling pathway; negative regulation of viral protein levels in host cell; positive regulation of mesenchymal cell proliferation; lipopolysaccharide-mediated signaling pathway; defense response to virus; response to nutrient; response to drug; cytokine and chemokine mediated signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; JAK-STAT cascade; regulation of transcription from RNA polymerase II promoter; negative regulation of angiogenesis; cellular response to insulin stimulus; response to hydrogen peroxide; response to mechanical stimulus; response to cytokine stimulus; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of transcription from RNA polymerase II promoter. Disease: Immunodeficiency 31a; Immunodeficiency 31b; Immunodeficiency 31c
尺寸1 :
0.03毫升
价格1 :
155美元
尺寸2 :
0.1毫升
价格2 :
220
size3 :
0.2毫升
价格3 :
295
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。