产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗组蛋白去乙酰化酶 6(pS22)抗体
目录 :
MBS8240627
规格 :
0.03毫升
价格 :
165美元
克隆性 :
多克隆
宿主 :
unidentified
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
MyBioSource 产品网页
图像
图像 1 :
MyBioSource MBS8240627 图像 1
Western blot analysis of Histone Deacetylase 6 (pS22) expression in HepG2 (A), HeLa (B) whole cell lysates.
图像 2 :
MyBioSource MBS8240627 图像 2
Immunohistochemical analysis of Histone Deacetylase 6 (pS22) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
图像 3 :
MyBioSource MBS8240627 图像 3
Immunofluorescent analysis of Histone Deacetylase 6 (pS22) staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
产品信息
目录号 :
MBS8240627
产品类型 :
抗体
产品全称 :
抗组蛋白去乙酰化酶 6(pS22)抗体
产品简称 :
[组蛋白去乙酰化酶 6]
产品名称同义词 :
[KIAA0901;组蛋白去乙酰化酶 6;HD6]
其他名称 :
[组蛋白去乙酰化酶 6;组蛋白去乙酰化酶 6;组蛋白去乙酰化酶 6;组蛋白去乙酰化酶 6]
产品基因名称 :
[HDAC6]
其他基因名称 :
[HDAC6;HDAC6;HD6;JM21;CPBHM;PPP1R90;KIAA0901;HD6]
UniProt数据库进入名 :
HDAC6_HUMAN
克隆性 :
多克隆
宿主 :
未知
反应物种 :
Human, Monkey
序列长度 :
1215
特异性 :
Recognizes endogenous levels of Histone Deacetylase 6 (pS22) protein.
纯度 :
The antibody was purified by immunogen affinity chromatography.
形式 :
液体0.42% 钾磷酸盐, 0.87% 氯化钠, pH值7.3, 30% 甘油, 和0.01% 叠氮化钠
储存稳定性 :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF), 免疫细胞化学(免疫细胞化学)
应用笔记 :
Dilution: WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500)
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
image3头 :
免疫荧光(IF)
其它信息1 :
Source: Rabbit. Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Histone Deacetylase 6 (pS22). The exact sequence is proprietary.
产品描述 :
兔多克隆抗体组蛋白去乙酰化酶 6(pS22)
NCBI GI登录号 :
13128864
NCBI登录号 :
NP_006035.2
NCBI基因登录号 :
NM_006044.2
UniProt数据库登录号 :
Q9UBN7
NCBI分子量 :
114,361 Da
NCBI信号通路 :
Alcoholism Pathway (585563); Alcoholism Pathway (587116); Assembly Of The Primary Cilium Pathway (1268846); Cell Cycle Pathway (198811); Cellular Response To Heat Stress Pathway (1270421); Cellular Responses To Stress Pathway (1270414); Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway (1268891); Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway (1268889); Disease Pathway (1268854); Diseases Of Signal Transduction Pathway (1268855)
NCBI总结 :
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
HDAC6: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15. Belongs to the histone deacetylase family. HD type 2 subfamily. Protein type: Ubiquitin conjugating system; EC 3.5.1.98; Nuclear receptor co-regulator; Deacetylase. Chromosomal Location of Human Ortholog: Xp11.23. Cellular Component: microtubule; histone deacetylase complex; dendrite; leading edge; perikaryon; inclusion body; caveola; cytosol; nucleoplasm; dynein complex; microtubule associated complex; perinuclear region of cytoplasm; axon; cytoplasmic microtubule; cytoplasm; nucleus. Molecular Function: zinc ion binding; histone deacetylase binding; microtubule binding; beta-catenin binding; beta-tubulin binding; Hsp90 protein binding; misfolded protein binding; actin binding; NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; enzyme binding; tubulin deacetylase activity; NAD-dependent histone deacetylase activity (H3-K14 specific); ubiquitin protein ligase binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; polyubiquitin binding; tau protein binding; alpha-tubulin binding. Biological Process: negative regulation of proteolysis; response to misfolded protein; protein polyubiquitination; positive regulation of signal transduction; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; transcription, DNA-dependent; negative regulation of microtubule depolymerization; regulation of fat cell differentiation; macroautophagy; organelle organization and biogenesis; response to toxin; misfolded or incompletely synthesized protein catabolic process; histone deacetylation; regulation of gene expression, epigenetic; response to organic substance; intracellular protein transport; protein complex disassembly; lysosome localization; protein amino acid deacetylation; negative regulation of oxidoreductase activity; regulation of receptor activity; negative regulation of transcription, DNA-dependent; negative regulation of protein complex disassembly. Disease: Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia
尺寸1 :
0.03毫升
价格1 :
165美元
尺寸2 :
0.1毫升
价格2 :
245
size3 :
0.2毫升
价格3 :
350
更多信息或购买 :
MyBioSource 产品网页
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。