产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
抗叉头框蛋白01(pS256)抗体
目录 :
MBS8241771
规格 :
0.03毫升
价格 :
165美元
克隆性 :
多克隆
宿主 :
兔
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, 牛, 斑马鱼
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀
更多信息或购买 :
图像
图像 1 :
Western blot analysis of STAT1 (pY701) expression in HEK293T (A), NIH3T3 (B), mouse brain (C), COS7 (D) whole cell lysates.
图像 2 :
Immunohistochemical analysis of STAT1 (pY701) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
图像 3 :
Immunofluorescent analysis of STAT1 (pY701) staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
产品信息
目录号 :
MBS8241771
产品类型 :
抗体
产品全称 :
抗叉头框蛋白01(pS256)抗体
产品简称 :
[叉头框蛋白01]
产品名称同义词 :
[FKHR; FOXO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma]
其他名称 :
[Forkhead box protein O1; Forkhead box protein O1; forkhead box protein O1; forkhead box O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma]
产品基因名称 :
[叉头框蛋白01]
其他基因名称 :
[叉头框蛋白01;叉头框蛋白01;FKH1;FKHR;FOXO1A;FKHR;FOXO1A]
UniProt数据库进入名 :
FOXO1_HUMAN
克隆性 :
多克隆
宿主 :
兔
反应物种 :
人类, 小鼠, 大鼠, 牛, 猪, 斑马鱼
序列长度 :
655
特异性 :
Recognizes endogenous levels of FOXO1 (pS256) protein.
纯度 :
The antibody was purified by immunogen affinity chromatography.
形式 :
液体0.42% 钾磷酸盐, 0.87% 氯化钠, pH值7.3, 30% 甘油, 和0.01% 叠氮化钠
储存稳定性 :
Shipping:Blue ice. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF), 免疫细胞化学(免疫细胞化学), 免疫沉淀(免疫沉淀)
应用笔记 :
Western Blot: (1/500 - 1/1000). Immunohistochemistry: (1/100 - 1/200). Immunofluorescence/Immunocytochemistry: (1/100 - 1/500). Immunoprecipitation: (1/10 - 1/100)
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
image3头 :
免疫荧光(IF)
其它信息1 :
Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human FOXO1 (pS256). The exact sequence is proprietary.
产品描述 :
兔多克隆抗体叉头框蛋白01(pS256)
NCBI GI登录号 :
116241368
NCBI登录号 :
Q12778.2
UniProt数据库登录号 :
Q12778
NCBI信号通路 :
AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); AGE/RAGE Pathway (698754); AKT Phosphorylates Targets In The Nucleus Pathway (1269190); AKT-mediated Inactivation Of FOXO1A Pathway (1270342); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adaptive Immune System Pathway (1269171); Adipogenesis Pathway (198832); Androgen Receptor Signaling Pathway (198806)
NCBI总结 :
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
UniProt数据库总结 :
FOXO1A: a transcription factor of the forkhead family. A central regulator of metabolism in several cell types. May play an important role in myogenic growth and differentiation, and in the regulation of lipolysis in adipocytes by controlling the expression of adipose triglyceride lipase (ATGL), the rate-limiting lipolytic enzyme. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. Contains 1 fork-head domain. Protein type: Nuclear receptor co-regulator; Oncoprotein; DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 13q14.1. Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus. Molecular Function: beta-catenin binding; chromatin binding; protein binding; protein phosphatase 2A binding; sequence-specific DNA binding; ubiquitin protein ligase binding. Biological Process: anatomical structure morphogenesis; apoptosis; autophagy; blood vessel development; cell differentiation; cell glucose homeostasis; cellular response to insulin stimulus; cellular response to starvation; endocrine pancreas development; epidermal growth factor receptor signaling pathway; fat cell differentiation; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; negative regulation of apoptosis; negative regulation of fat cell differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of apoptosis; positive regulation of autophagy; positive regulation of gluconeogenesis; positive regulation of protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid acetylation; response to DNA damage stimulus; thermoregulation; transcription, DNA-dependent. Disease: Rhabdomyosarcoma 2
尺寸1 :
0.03毫升
价格1 :
165美元
尺寸2 :
0.1毫升
价格2 :
245
size3 :
0.2毫升
价格3 :
350
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华，公司愿景是“生物研究试剂的源头”，现在位于圣地亚哥市。
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