抗体

抗过氧化物酶体增殖物激活受体γ抗体

MBS8242283

0.03毫升

155美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠, 狗

免疫印迹, 免疫组化, 免疫细胞化学

抗体

抗过氧化物酶体增殖物激活受体γ抗体

[过氧化物酶体增殖物激活受体γ]

[NR1C3; Peroxisome proliferator-activated receptor gamma; PPAR-gamma; Nuclear receptor subfamily 1 group C member 3]

[Peroxisome proliferator-activated receptor gamma; Peroxisome proliferator-activated receptor gamma; peroxisome proliferator-activated receptor gamma; peroxisome proliferator activated receptor gamma; Nuclear receptor subfamily 1 group C member 3]

[过氧化物酶体增生物激活受体gamma]

[过氧化物酶体增生物激活受体gamma;过氧化物酶体增生物激活受体gamma;GLM1;CIMT1;NR1C3;PPARG1;PPARG2;PPARgamma;NR1C3;过氧化物酶体增殖物激活受体γ]

PPARG_HUMAN

多克隆

兔

人类, 小鼠, 大鼠, 狗, 兔

505

Recognizes endogenous levels of PPAR gamma protein.

The antibody was purified by immunogen affinity chromatography.

液体0.42% 钾磷酸盐, 0.87% 氯化钠, pH值7.3, 30% 甘油, 和0.01% 叠氮化钠

Shipped at 4°C. Upon delivery aliquot and store at -20°C for one year. Avoid freeze/thaw cycles.

免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF), 免疫细胞化学(免疫细胞化学)

Western Blot: (1/500 - 1/1000). Immunohistochemistry: (1/100 - 1/200). Immunofluorescence/Immunocytochemistry: (1/100 - 1/500)

免疫印迹(免疫印迹)

免疫组化(免疫组化)

免疫荧光(IF)

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PPAR gamma. The exact sequence is proprietary.

兔多克隆抗体过氧化物酶体增殖物激活受体γ

13432234

P37231.3

P37231

AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adipogenesis Pathway (198832); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Developmental Biology Pathway (1270302); Energy Metabolism Pathway (198907); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (1270010); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); Huntington's Disease Pathway (83100)

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

PPAR-gamma: a transcription factor, member of the nuclear hormone receptor superfamily. Receptor for hypolipidemic drugs and fatty acids. Preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage. Regulator of adipogenesis and lipid metabolism, modulates insulin sensitivity, cell proliferation and inflammation. Phosphorylated and inhibited by MAP kinase. Heterodimerizes with the retinoid X receptor. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Two splice-variant isoforms have been described. Protein type: Nuclear receptor; DNA-binding. Chromosomal Location of Human Ortholog: 3p25. Cellular Component: cytosol; Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm; nucleus; perinuclear region of cytoplasm. Molecular Function: alpha-actinin binding; arachidonic acid binding; chromatin binding; DNA binding; drug binding; enzyme binding; estrogen receptor binding; identical protein binding; ligand-dependent nuclear receptor activity; ligand-dependent nuclear receptor transcription coactivator activity; prostaglandin receptor activity; protein binding; protein phosphatase binding; retinoid X receptor binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription activator binding; transcription factor activity; zinc ion binding. Biological Process: brown fat cell differentiation; caspase activation; cell fate commitment; cell maturation; cellular response to insulin stimulus; diet induced thermogenesis; epithelial cell differentiation; fatty acid oxidation; G-protein coupled receptor protein signaling pathway; gene expression; glucose homeostasis; heart development; innate immune response; lipid homeostasis; lipid metabolic process; lipoprotein transport; long-chain fatty acid transport; low-density lipoprotein receptor biosynthetic process; monocyte differentiation; negative regulation of acute inflammatory response; negative regulation of cell growth; negative regulation of collagen biosynthetic process; negative regulation of smooth muscle cell proliferation; negative regulation of telomerase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; organ regeneration; placenta development; positive regulation of fat cell differentiation; positive regulation of fatty acid oxidation; positive regulation of oligodendrocyte differentiation; positive regulation of phagocytosis, engulfment; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of blood pressure; regulation of circadian rhythm; response to caffeine; response to cold; response to estrogen stimulus; response to lipid; response to low density lipoprotein stimulus; response to mechanical stimulus; response to nutrient; response to retinoic acid; response to starvation; response to vitamin A; rhythmic process; signal transduction; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter; white fat cell differentiation. Disease: Carotid Intimal Medial Thickness 1; Diabetes Mellitus, Noninsulin-dependent; Lipodystrophy, Familial Partial, Type 3; Obesity

0.03毫升

155美元

0.1毫升

220

0.2毫升

295