抗体

抗神经生长因子乙抗体

MBS8242378

0.03毫升

155美元

多克隆

兔

未共轭

人类, 牛

抗体

抗神经生长因子乙抗体

[神经生长因子乙]

[NGFB;β神经生长因子;乙神经生长因子]

[β神经生长因子;β神经生长因子;β神经生长因子;神经生长因子]

[神经生长因子]

[神经生长因子;神经生长因子;NGFB;HSAN5;乙神经生长因子;NGFB;乙神经生长因子]

NGF_HUMAN

多克隆

兔

人类, 牛, 猪

241

Recognizes endogenous levels of NGF beta protein.

The antibody was purified by affinity chromatography.

液体0.42% 钾磷酸盐, 0.87% 氯化钠, pH值7.3, 30% 甘油, 和0.01% 叠氮化钠

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

免疫印迹(免疫印迹)

Western Blot: (1/500 - 1/1000)

免疫印迹(免疫印迹)

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NGF beta. The exact sequence is proprietary.

兔多克隆抗体神经生长因子乙

90110037

P01138.3

P01138

26,959 Da

ARMS-mediated Activation Pathway (1269471); Activation Of TRKA Receptors Pathway (1269461); Apoptosis Pathway (83060); Apoptosis Pathway (470); Axonal Growth Stimulation Pathway (1269457); BDNF Signaling Pathway (712093); Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (1269447); Ceramide Signalling Pathway (1269455); Frs2-mediated Activation Pathway (1269470); Id Signaling Pathway (198871)

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

NGF: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Homodimer. Belongs to the NGF-beta family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1p13.1. Cellular Component: cytoplasmic membrane-bound vesicle; endosome; extracellular region; Golgi lumen. Molecular Function: growth factor activity; metalloendopeptidase inhibitor activity; nerve growth factor receptor binding; protein binding; receptor signaling protein activity. Biological Process: activation of MAPKK activity; cell-cell signaling; induction of apoptosis via death domain receptors; negative regulation of apoptosis; negative regulation of cell cycle; negative regulation of neuron apoptosis; nerve growth factor processing; nerve growth factor receptor signaling pathway; neurite morphogenesis; neuron apoptosis; peripheral nervous system development; phosphoinositide-mediated signaling; phospholipase C activation; positive regulation of apoptosis; positive regulation of axon extension; positive regulation of axonogenesis; positive regulation of collateral sprouting; positive regulation of neuron maturation; positive regulation of protein ubiquitination; Ras protein signal transduction; regulation of axonogenesis; regulation of caspase activity; regulation of neuron differentiation; regulation of neurotransmitter secretion; regulation of release of sequestered calcium ion into cytosol; sensory perception of pain; small GTPase mediated signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway. Disease: Neuropathy, Hereditary Sensory And Autonomic, Type V

0.03毫升

155美元

0.1毫升

220

0.2毫升

295