蛋白

重组人类IRF5蛋白

MBS8249321

0.01毫克

255美元

重组蛋白

重组人类IRF5蛋白

[IRF5]

[干扰素调节因子5;IRF-5]

[interferon regulatory factor 5 isoform b; Interferon regulatory factor 5; interferon regulatory factor 5; interferon regulatory factor 5]

[IRF5]

[IRF5;IRF5;SLEB10;IRF-5]

IRF5_HUMAN

大肠杆菌

人类

498

MNQSIPVAPT PPRRVRLKPW LVAQVNSCQY PGLQWVNGEK KLFCIPWRHA TRHGPSQDGD NTIFKAWAKE TGKYTEGVDE ADPAKWKANL RCALNKSRDF RLIYDGPRDM PPQPYKIYEV CSNGPAPTDS QPPEDYSFGA GEEEEEEEEL QRMLPSLSLT EDVKWPPTLQ PPTLRPPTLQ PPTLQPPVVL GPPAPDPSPL APPPGNPAGF RELLSEVLEP GPLPASLPPA GEQLLPDLLI SPHMLPLTDL EIKFQYRGRP PRALTISNPH GCRLFYSQLE ATQEQVELFG PISLEQVRFP SPEDIPSDKQ RFYTNQLLDV LDRGLILQLQ GQDLYAIRLC QCKVFWSGPC ASAHDSCPNP IQREVKTKLF SLEHFLNELI LFQKGQTNTP PPFEIFFCFG EEWPDRKPRE KKLITVQVVP VAARLLLEMF SGELSWSADS IRLQISNPDL KDRMVEQFKE LHHIWQSQQR LQPVAQAPPG AGLGVGQGPW PMHPAGMQLE HHHHHH

Greater than 95% as determined by reducing SDS-PAGE.

Liquid in a a 0.2 um filtered solution of 20mM Tris, 150mM Nacl, 30% Glycerol, 1mM DTT, pH 8.0.

Store it at -20°C to -80°C for one year. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

ELISA (EIA), Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)

Quality Control: Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Recombinant Human IRF5 Protein is produced by our E. coli expression system and the target gene encoding Met1-Gln498 is expressed with a 6His tag at the C-terminus.

291190719

NP_001092097.2

NM_001098627.3

Q13568

Apoptosis Pathway (198797); Cytokine Signaling In Immune System Pathway (1269310); Direct P53 Effectors Pathway (137939); Immune System Pathway (1269170); Interferon Signaling Pathway (1269311); Interferon Alpha/beta Signaling Pathway (1269312); Interferon Gamma Signaling Pathway (1269314); Regulation Of Toll-like Receptor Signaling Pathway (920955); Senescence And Autophagy In Cancer Pathway (198780); Toll-like Receptor Signaling Pathway (198855)

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

IRF5: Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Homodimer, when phosphorylated. Belongs to the IRF family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 7q32. Cellular Component: cytoplasm; cytosol; nucleus. Molecular Function: protein binding. Biological Process: positive regulation of apoptosis; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of interleukin-12 production; positive regulation of transcription from RNA polymerase II promoter; response to muramyl dipeptide; response to peptidoglycan. Disease: Inflammatory Bowel Disease 14; Systemic Lupus Erythematosus, Susceptibility To, 10

0.01毫克

255美元

0.05毫克

635

0.5毫克

2370