产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
CD86抗体
目录 :
MBS831174
规格 :
0.1毫升
价格 :
455美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
1B3
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS831174
产品类型 :
抗体
产品全称 :
CD86抗体
产品简称 :
CD86
产品名称同义词 :
Monoclonal CD86; Anti-CD86; CD86 antigen; CD86; CD 86; Cluster of Differentiation 86; B72; T-lymphocyte activation antigen CD86; Cluster of differentiation 86; B 72; CTLA-4 counter-receptor B7.2; CD-86; B-lymphocyte activation antigen B7 2
其他名称 :
CD86, partial; T-lymphocyte activation antigen CD86; T-lymphocyte activation antigen CD86; CD86 molecule; Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD_antigen: CD86
产品基因名称 :
CD86
其他基因名称 :
CD86;CD86;B70;B7-2;B7.2;LAB72;CD28LG2;CD28LG2
UniProt数据库进入名 :
CD86_HUMAN
克隆性 :
单克隆
抗体亚型 :
IgG1
克隆 :
1B3
宿主 :
小鼠
反应物种 :
人类
序列长度 :
323
形式 :
液体含0.03% 叠氮化钠
浓度 :
1.0毫克/毫升
储存稳定性 :
Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
检测过的应用 :
酶联免疫吸附测定(EIA), 免疫印迹(免疫印迹)
应用笔记 :
ELISA: 1:10, 000。 WB: 1:200-1:1000
其它信息1 :
Biological Significance: CD86 is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.
其他信息2 :
Immunogen: CD86 antibody was raised in Mouse using a purified recombinant fragment of human CD86 expressed in E Coli as the immunogen.
产品种类 :
免疫学
产品描述 :
小鼠单克隆CD86抗体
NCBI GI登录号 :
49456643
NCBI登录号 :
CAG46642.1
UniProt数据库登录号 :
P42081
NCBI分子量 :
28,420 Da
NCBI信号通路 :
Adaptive Immune System Pathway (366160); Allograft Rejection Pathway (920963); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); CD28 Co-stimulation Pathway (119553); CD28 Dependent PI3K/Akt Signaling Pathway (119554); CD28 Dependent Vav1 Pathway (119555); CTLA4 Inhibitory Signaling Pathway (119556)
NCBI总结 :
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
UniProt数据库总结 :
CD86: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Immunoglobulin superfamily. Chromosomal Location of Human Ortholog: 3q21. Cellular Component: cell surface; intracellular membrane-bound organelle; plasma membrane; integral to membrane; external side of plasma membrane. Molecular Function: protein binding; coreceptor activity; receptor activity; receptor binding. Biological Process: positive regulation of lymphotoxin A biosynthetic process; nerve growth factor receptor signaling pathway; viral reproduction; T cell activation; negative regulation of T cell anergy; positive regulation of interleukin-2 biosynthetic process; positive regulation of transcription, DNA-dependent; myeloid dendritic cell differentiation; positive regulation of activated T cell proliferation; positive regulation of interleukin-4 biosynthetic process; positive regulation of T-helper 2 cell differentiation; cell-cell signaling; T cell proliferation during immune response; positive regulation of cell proliferation; response to yeast; defense response to virus; aging; response to drug; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; B cell activation; T cell costimulation; toll-like receptor signaling pathway; innate immune response; immune response
尺寸1 :
0.1毫升
价格1 :
455美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。