抗体

CD19抗体

MBS831357

0.1毫升

270美元

单克隆

小鼠

未共轭

[2E2B6B10]

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

CD19抗体

[CD19]

[Monoclonal CD19; Anti-CD19; B-lymphocyte antigen CD19; CD 19; CD19; Cluster of Differentiation 19; CD-19]

[CD19, partial; CD19; B-lymphocyte antigen CD19; CD19 molecule; CD19]

[CD19]

[CD19;CD19;B4;CVID3]

Q71UW0_HUMAN

单克隆

IgG2a

[2E2B6B10]

小鼠

人类

92

Purified liquid in PBS with 0.03% sodium azide.

1.0毫克/毫升

Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

酶联免疫吸附测定(EIA), 免疫组化(免疫组化), 免疫印迹(免疫印迹)

ELISA: 1:10, 000。 IHC: 1:200-1:1000。 WB: 1:500-1:2000

Immunohistochemical staining

免疫印迹

Biological Significance: CD19 is a protein that in humans is encoded by the CD19 gene. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase.

Immunogen: CD19 antibody was raised in Mouse using a purified recombinant fragment of human CD19 expressed in E Coli as the immunogen.

免疫学

小鼠单克隆CD19抗体

4105281

AAD02340.1

Q71UW0

10,185 Da

Adaptive Immune System Pathway (366160); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (576249); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); Constitutive Signaling By Aberrant PI3K In Cancer Pathway (685535); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Disease Pathway (530764)

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

CD19: a cell surface molecule which assembles with the antigen receptor of B lymphocytes. A critical signal transduction molecule that regulates B lymphocyte development, activation, and differentiation. Ligation increases intracellular calcium levels and decreases the threshold for antigen receptor signaling. Germinal center formation is significantly reduced in CD19-deficient mice. Protein type: Cell surface; Membrane protein, integral. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: protein complex; integral to plasma membrane; plasma membrane; external side of plasma membrane. Molecular Function: receptor signaling protein activity. Biological Process: epidermal growth factor receptor signaling pathway; regulation of immune response; B cell receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; cell surface receptor linked signal transduction; nerve growth factor receptor signaling pathway; innate immune response; cellular defense response; positive regulation of release of sequestered calcium ion into cytosol. Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 3

0.1毫升

270美元