人类, 小鼠, 大鼠, 狗, 牛
图像 1 :
Western Blot analysis using CCL5 antibody. CCL5 antibody used at 1.25 ug/ml to detect target protein.
[Polyclonal CCL5 antibody, Anti-CCL5 antibody, CCL-5 antibody, CCL 5, CCL5, CCL-5, Chemokine (C-C motif) ligand 5 antibody, CCL 5 antibody]
[C-C motif chemokine 5; C-C motif chemokine 5; C-C motif chemokine 5; chemokine (C-C motif) ligand 5; MuRantes; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES]
[Ccl5; Ccl5; SISd; Scya5; RANTES; TCP228; MuRantes; Scya5]
牛, 狗, 豚鼠, 马, 人类, 小鼠, 猪, 兔, 大鼠
Liquid in PBS buffer with 0.09% NaN 3 , and 2% Sucrose.
Store at 4°C for short term, -20°C for long term. Avoid repeat freeze-thaws.
Biological Significance: Recently, it has been shown that genetic polymorphisms can result in diminished expression of CCL5, which results in increased susceptibility to and progression of infectious diseases. CCL5, together with Th cytokine mRNA expression, is temporally up-regulated during pneumococcal carriage. CCL5 is an essential factor for the induction and maintenance of protective pneumococcal immunity
Immunogen: Synthetic peptide directed towards the middle region of mouse CCL5.
NCBI GI登录号 :
Chagas Disease (American Trypanosomiasis) Pathway (147810); Chagas Disease (American Trypanosomiasis) Pathway (147795); Chemokine Receptors Bind Chemokines Pathway (1168363); Chemokine Signaling Pathway (99271); Chemokine Signaling Pathway (672435); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (1168361); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Cytosolic DNA-sensing Pathway (125146)
CCL5: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T- cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils. By mitogens. T-cell and macrophage specific. Belongs to the intercrine beta (chemokine CC) family. Protein type: Cell adhesion; Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine. Cellular Component: extracellular space; cell; cytoplasm; extracellular region; intracellular. Molecular Function: heparin binding; protein homodimerization activity; protein self-association; cytokine activity; receptor signaling protein tyrosine kinase activator activity; phosphoinositide phospholipase C activity; protein kinase activity; CCR1 chemokine receptor binding; chemokine activity; chemokine receptor binding; chemokine receptor antagonist activity; phospholipase activator activity; chemoattractant activity; CCR5 chemokine receptor binding. Biological Process: exocytosis; positive regulation of cell adhesion; positive regulation of osteoclast differentiation; positive regulation of smooth muscle cell proliferation; response to toxin; positive regulation of smooth muscle cell migration; chemotaxis; positive regulation of cell-cell adhesion mediated by integrin; protein amino acid phosphorylation; pseudopodium formation; positive regulation of homotypic cell-cell adhesion; leukocyte adhesion; cell-cell signaling; positive chemotaxis; calcium ion transport; lipopolysaccharide-mediated signaling pathway; protein kinase B signaling cascade; positive regulation of T cell proliferation; inflammatory response; lymphocyte chemotaxis; protein tetramerization; phospholipase D activation; neutrophil activation; negative regulation of G-protein coupled receptor protein signaling pathway; MAPKKK cascade; positive regulation of cellular biosynthetic process; cellular calcium ion homeostasis; positive regulation of phosphoinositide 3-kinase cascade; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; cellular protein complex assembly; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of viral genome replication; response to cytokine stimulus; eosinophil chemotaxis; positive regulation of fever; immune response; positive regulation of calcium ion transport; positive regulation of neuron differentiation; positive regulation of defense response to virus by host; regulation of insulin secretion; positive regulation of epithelial cell proliferation; positive regulation of phosphorylation; regulation of T cell activation; positive regulation of cell migration
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308