TIMELESS抗体 | MyBioSource MBS832534 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

TIMELESS抗体

MBS832534

规格 :

0.1毫克

价格 :

370美元

克隆性 :

多克隆

宿主 :

兔

共轭标签 :

未共轭

反应物种 :

人类, 小鼠, 大鼠, 狗, 牛, 斑马鱼

应用 :

免疫印迹

更多信息或购买 :

MyBioSource 产品网页

图像

图像 1 :

TIMELESS antibody (MBS832534) used at 0.2-1 ug/ml to detect target protein.

产品信息

目录号 :

MBS832534

产品类型 :

抗体

产品全称 :

TIMELESS抗体

产品简称 :

[TIMELESS]

产品名称同义词 :

[Polyclonal TIMELESS; Anti-TIMELESS; Drosophila; timeless homolog]

其他名称 :

[protein timeless homolog; Protein timeless homolog; protein timeless homolog; timeless circadian clock]

产品基因名称 :

[TIMELESS]

其他基因名称 :

[TIMELESS;TIMELESS;TIM;TIM1;hTIM;hTIM]

UniProt数据库进入名 :

TIM_HUMAN

克隆性 :

多克隆

宿主 :

兔

反应物种 :

牛, 狗, 豚鼠, 马, 人类, 小鼠, 猪, 兔, 大鼠, 羊, 斑马鱼

序列长度 :

1208

形式 :

Liquid in PBS with 0.09% Sodium Azide

浓度 :

1毫克/毫升

储存稳定性 :

4°C short term, -20°C long term

检测过的应用 :

免疫印迹(免疫印迹)

应用笔记 :

WB: 2.5 ug/ml. TIMELESS Blocking Peptide is also available for use as a blocking control in assays to test for specificity of this TIMELESS antibody

image1头 :

免疫印迹(免疫印迹)

其它信息1 :

Biological Significance: The human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.

其他信息2 :

Immunogen: Synthetic peptide directed toward the N terminal regiob of human TIMELESS

产品种类 :

脱氧核糖核酸&核糖核酸

产品描述 :

兔多克隆TIMELESS抗体

NCBI GI登录号 :

222136585

NCBI登录号 :

NP_003911

NCBI基因登录号 :

NM_003920.3

UniProt数据库登录号 :

Q9UNS1

NCBI信号通路 :

昼夜节律通路(137978)

NCBI总结 :

The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]

UniProt数据库总结 :

TIMELESS: Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules. Belongs to the timeless family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 12q13.3. Cellular Component: microtubule cytoskeleton; nuclear chromatin; nucleolus; nucleus. Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity. Biological Process: circadian rhythm; mitosis; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; regulation of cell proliferation; branching morphogenesis of a tube; cell division; response to abiotic stimulus; morphogenesis of an epithelium; negative regulation of transcription, DNA-dependent; response to DNA damage stimulus; detection of abiotic stimulus; lung development

尺寸1 :

0.1毫克

价格1 :

370美元

更多信息或购买 :

MyBioSource 产品网页

公司信息