抗体

PAD4抗体

MBS835768

0.1毫升

515美元

多克隆

兔

未共轭

免疫印迹, 免疫组化, 免疫细胞化学, 免疫组化-石蜡切片

抗体

PAD4抗体

PAD4

Polyclonal PAD4; Anti-PAD4; peptidyl arginine deiminase type V; PADI5; PAD 4; protein-arginine deiminase type IV; PDI5; HL-60 PAD; PADI4; PAD-4; PADI-H protein; protein-arginine deiminase type-4; PDI4; PAD4; PAD

protein-arginine deiminase type-4; Protein-arginine deiminase type-4; protein-arginine deiminase type-4; peptidyl arginine deiminase, type IV; HL-60 PAD; Peptidylarginine deiminase IV; Protein-arginine deiminase type IV

PAD4

PADI4;PADI4;PAD;PAD4;PDI4;PDI5;PADI5;PADI5;PDI5

PADI4_HUMAN

多克隆

IgG

兔

人类

663

PAD4 antibody was purified by antigen-affinity chromatography

Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.

0.73毫克/毫升

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

免疫荧光(IF), 免疫细胞化学(免疫细胞化学), 免疫组化(免疫组化)石蜡, 免疫印迹(免疫印迹)

IF:1:100-1:500。 ICC:1:100-1:500。 免疫组化-P:1:100-1:500。 WB: 1:500-1:3000

Biological Significance: This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.

Proteases, Inhibitors, Purified Polyclonal Antibodies

亲和纯化兔多克隆PAD4抗体

216548487

NP_036519.2

NM_012387.2

Q9UM07

74 kDa

Protein Citrullination Pathway (142167); Protein Citrullination Pathway (138213)

This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]

PADI4: Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at Arg-8 and/or Arg-17 and histone H4 at Arg-3 , which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at Arg-2142 , which favors its interaction with NCOA2/GRIP1. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context. Belongs to the protein arginine deiminase family. Protein type: Nuclear receptor co-regulator; Hydrolase; EC 3.5.3.15. Chromosomal Location of Human Ortholog: 1p36.13. Cellular Component: cytoplasm; nucleus. Molecular Function: arginine deiminase activity; protein binding; calcium ion binding; protein-arginine deiminase activity. Biological Process: chromatin remodeling; nucleosome assembly; regulation of transcription, DNA-dependent; transcription, DNA-dependent; stem cell maintenance; protein modification process; innate immune response; chromatin modification; peptidyl-citrulline biosynthetic process from peptidyl-arginine. Disease: Rheumatoid Arthritis

0.1毫升

515美元