抗体

IGF-1R抗体

MBS837677

0.05毫克

275美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫细胞化学

抗体

IGF-1R抗体

IGF-1R

多克隆IGF-1R;抗IGF-1R;IGF-1;IGF-1R;IGF-R;IGF-R 1;胰岛素样生长因子1;胰岛素样生长因子1受体;Ab 1161

胰岛素样生长因子1受体;胰岛素样生长因子1受体;胰岛素样生长因子1受体;胰岛素样生长因子Ⅰ受体;胰岛素样生长因子Ⅰ受体;IGF-I受体

IGF-1R

Igf1r; Igf1r; hyft; CD221; IGF-1R; D930020L01; A330103N21Rik; IGF-I receptor

IGF1R_MOUSE

多克隆

兔

人类, 小鼠, 大鼠

1369

IGF-1R antibody was purified by immunoaffinity chromatography.

Liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium azide and 50% Glycerol.

1毫克/毫升

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

免疫荧光(IF), 免疫组化(免疫组化), 免疫印迹(免疫印迹)

IF: 1:100-1:200。 IHC: 1:50-1:100。 WB: 1:500-1:1000

Biological Significance: IGF-1R is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growth-promoting effect of this receptor.

Immunogen: Peptide sequence derived from Human IGF-1R

信号转导

兔多克隆IGF-1R抗体

112983656

NP_034643.2

NM_010513.2

AMPK Signaling Pathway (989651); AMPK Signaling Pathway (992181); Adherens Junction Pathway (83267); Adherens Junction Pathway (481); Apoptosis Pathway (198339); Endochondral Ossification Pathway (198336); Endocytosis Pathway (102286); Endocytosis Pathway (102181); Focal Adhesion Pathway (83264); Focal Adhesion Pathway (478)

IGF1R: a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541. Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; TK group; InsR family. Cellular Component: neuron projection; intracellular membrane-bound organelle; membrane; integral to membrane; plasma membrane; caveola; receptor complex. Molecular Function: identical protein binding; insulin-like growth factor binding; nucleotide binding; G-protein alpha-subunit binding; transmembrane receptor protein tyrosine kinase activity; insulin receptor binding; insulin-like growth factor receptor activity; protein kinase activity; transferase activity; insulin binding; protein binding; insulin-like growth factor I binding; protein-tyrosine kinase activity; insulin receptor substrate binding; transferase activity, transferring phosphorus-containing groups; phosphoinositide 3-kinase binding; kinase activity; ATP binding. Biological Process: positive regulation of DNA metabolic process; epidermis development; inactivation of MAPKK activity; protein heterooligomerization; protein amino acid autophosphorylation; exocrine pancreas development; protein amino acid phosphorylation; regulation of JNK cascade; mammary gland development; positive regulation of MAPKKK cascade; male sex determination; neurite development; protein tetramerization; positive regulation of cytokinesis; negative regulation of protein kinase B signaling cascade; phosphoinositide-mediated signaling; positive regulation of mitosis; negative regulation of MAPKKK cascade; negative regulation of transcription factor activity; positive regulation of protein kinase B signaling cascade; organ morphogenesis; insulin-like growth factor receptor signaling pathway; axonogenesis; establishment of cell polarity; immune response; brain development; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of DNA replication; negative regulation of apoptosis; positive regulation of cell migration

0.05毫克

275美元