抗体

淋巴细胞型选择素/CD62L抗体

MBS840167

0.03毫克

150美元

多克隆

兔

未共轭

免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀

抗体

淋巴细胞型选择素/CD62L抗体

[淋巴细胞型选择素/CD62L]

[SELL;淋巴细胞粘连分子1]

[L-selectin; L-selectin; L-selectin; selectin L; CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; CD_antigen: CD62L]

[SELL;SELL;TQ1;LAM1;LEU8;LNHR;LSEL;CD62L;LYAM1;PLNHR;LECAM1;LNHR;LYAM1;LAM-1;LECAM1]

LYAM1_HUMAN

多克隆

IgG

兔

人类

385

The antibody recognizes L-Selectin in human sample, and in a lesser extent to mouse, and rat samples.

亲和纯化

100 ug (0.5mg/ml) protein A purified rabbit anti-L-Selectin polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. Appearance: Colorless liquid

0.5毫克/毫升

Store at -20°C. For long term storage, aliquot and freeze at –70°C. Avoid repeated freeze/defrost cycles.

免疫印迹(免疫印迹), 免疫沉淀(免疫沉淀), 免疫荧光(IF), 免疫组化(免疫组化)

The antibody can be used for Western blotting (0.5-4 ug/ml). Based on researcher’s feedback, it can also be used in immunoprecipitation (10-20 ug/ml) and immunohistochemistry (10-20 ug/ml). However, the optimal concentrations should be determined individually.

试验数据

Immunogen: Synthetic peptide surrounding amino acid 69 of human L-Selectin

Handling: The antibody solution should be gently mixed before use.

Background: Selectins are a family of carbohydrate-binding proteins involved in mediating cellular interactions with leukocytes. E-Selectin (also called ELMA-1) expressed on endothelial cells. L-Selectin (also called LECAM-1) is expressed on the majority of B and naïve T cells and on most monocytes, neurophils and eosinophils. P-Selectin (also called GMP-140) expressed on activated platelets and endothelial cells. Selectins interact with specific carbohydrates expressed by activated endothelial cells, monocytes, and neutrophils.

262206315

NP_000646.2

NM_000655.4

P14151

Adaptive Immune System Pathway (1269171); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (1269373); Hemostasis Pathway (1269340); Immune System Pathway (1269170); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (1269201)

This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

SELL: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q23-q25. Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane. Molecular Function: heparin binding; protein binding; protease binding; cell adhesion molecule binding; glycosphingolipid binding; carbohydrate binding. Biological Process: regulation of immune response; cell adhesion; blood coagulation; leukocyte migration; response to ATP. Disease: Iga Nephropathy, Susceptibility To, 1

0.03毫克

150美元

0.1毫克

300