产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
PECAM1抗体
目录 :
MBS8501612
规格 :
0.1毫升
价格 :
310美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
图像
图像 1 :
MyBioSource MBS8501612 图像 1
Western blot analysis of extracts of various Jurkat cell line, using PECAM1 antibody.
图像 2 :
MyBioSource MBS8501612 图像 2
图像 3 :
MyBioSource MBS8501612 图像 3
Immunohistochemistryof paraffin-embedded human colon cancer tissue using PECAM1 antibody.
产品信息
目录号 :
MBS8501612
产品类型 :
抗体
产品全称 :
PECAM1抗体
产品简称 :
[PECAM1]
产品名称同义词 :
[CD31;PECA1;GPIIA';PECAM-1;endoCAM]
其他名称 :
[血小板内皮细胞 粘连分子;血小板内皮细胞 粘连分子;血小板内皮细胞 粘连分子;血小板和内皮细胞 粘连分子1;EndoCAM;GPIIA';PECA1;CD_antigen:CD31]
产品基因名称 :
[PECAM1]
其他基因名称 :
[PECAM1;PECAM1;CD31;PECA1;GPIIA';PECAM-1;endoCAM;CD31/EndoCAM;PECAM-1]
克隆性 :
多克隆
抗体亚型 :
IgG
宿主 :
反应物种 :
人类, 小鼠, 大鼠
序列长度 :
738
纯度 :
亲和纯化
储存稳定性 :
Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化)
应用笔记 :
WB: 1:500-1:2000。 IHC: 1:25-1:100
image1头 :
免疫印迹(免疫印迹)
image2头 :
免疫组化(免疫组化)
image3头 :
免疫组化(免疫组化)
其它信息1 :
Immunogen: A synthetic peptide of human PECAM1. Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
产品种类 :
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
产品描述 :
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
NCBI GI登录号 :
313760624
NCBI登录号 :
NP_000433.4
NCBI基因登录号 :
NM_000442.4
UniProt数据库登录号 :
P16284
NCBI分子量 :
83kDa
NCBI信号通路 :
Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (106062); Hemostasis Pathway (106028); Integrin Cell Surface Interactions Pathway (106110); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494); Malaria Pathway (152665); Malaria Pathway (152657); PECAM1 Interactions Pathway (106064)
NCBI总结 :
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
UniProt数据库总结 :
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis ().
尺寸1 :
0.1毫升
价格1 :
310美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。