抗体

血管细胞粘附分子1小鼠单克隆抗体

MBS850175

0.1毫克

290美元

单克隆

小鼠

未共轭

6G9

免疫印迹, 酶联免疫吸附测定, 免疫组化, 酶免疫法

抗体

血管细胞粘附分子1小鼠单克隆抗体

血管细胞粘附分子1

CD106;MGC99561;INCAM-100;DKFZp779G2333;血管细胞粘附分子1

vascular cell adhesion protein 1 isoform a; Vascular cell adhesion protein 1; vascular cell adhesion protein 1; CD106 antigen; vascular cell adhesion molecule 1; INCAM-100; CD_antigen: CD106

血管细胞粘附分子1

血管细胞粘附分子1;血管细胞粘附分子1;CD106;INCAM-100;L1细胞粘附分子;V-CAM 1;VCAM-1

VCAM1_HUMAN

单克隆

6G9

小鼠

人类

739

腹水含0.03% 叠氮化钠

100微克/100微升

Store at 4 degree C, for long term storage, store at -20 degree C.

免疫印迹(免疫印迹), 免疫组化(免疫组化), 酶联免疫吸附测定(EIA)

WB: 1/500 - 1/2000, IHC: 1/200-1/1000, ELISA: Propose dilution 1/10000. Not yet tested in other applications.

Entrez Gene: 7412

Immunogen: Purified recombinant fragment of human VCAM1 expressed in E. Coli. Species: Mouse IgG1

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Background: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.Tissue specificity: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.INVITROGEN: CD106 is expressed on bone marrow stromal cells, myeloid cells, and endothelial cells.

4507875

NP_001069.1

NM_001078.3

81kDa

Adaptive Immune System Pathway (366160); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cellular Roles Of Anthrax Toxin Pathway (138076); Cytokine Signaling In Immune System Pathway (366171); Extracellular Matrix Organization Pathway (576262); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889)

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p32-p31. Cellular Component: Golgi apparatus; extracellular space; microvillus; cell surface; endoplasmic reticulum; early endosome; integral to membrane; apical part of cell; plasma membrane; podosome; sarcolemma; filopodium; external side of plasma membrane. Molecular Function: amine oxidase activity; integrin binding; cell adhesion molecule binding. Biological Process: response to nicotine; extracellular matrix organization and biogenesis; chronic inflammatory response; regulation of immune response; viral reproduction; cell-matrix adhesion; cytokine and chemokine mediated signaling pathway; heart development; response to lipopolysaccharide; heterophilic cell adhesion; leukocyte adhesion; response to ethanol; response to zinc ion; B cell differentiation; membrane to membrane docking; response to hypoxia; positive regulation of T cell proliferation; response to ionizing radiation; amine metabolic process; cell adhesion; leukocyte tethering or rolling; acute inflammatory response; response to nutrient; aging

0.1毫克

290美元