RET抗体 | MyBioSource MBS850230 产品信息

产品简要

公司名称 :

MyBioSource

产品类型 :

抗体

产品名称 :

RET抗体

MBS850230

规格 :

0.1毫克

价格 :

290美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

8D10C9

反应物种 :

人类

应用 :

免疫印迹, 酶联免疫吸附测定, 酶免疫法

更多信息或购买 :

MyBioSource 产品网页

产品信息

目录号 :

MBS850230

产品类型 :

抗体

产品全称 :

RET抗体

产品简称 :

RET

产品名称同义词 :

RET

其他名称 :

proto-oncogene tyrosine-protein kinase receptor Ret isoform c; Proto-oncogene tyrosine-protein kinase receptor Ret; proto-oncogene tyrosine-protein kinase receptor Ret; proto-oncogene c-Ret; receptor tyrosine kinase; RET transforming sequence; cadherin family member 12; hydroxyaryl-protein kinase; cadherin-related family member 16; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); ret proto-oncogene; Cadherin family member 12; Proto-oncogene c-RetCleaved into the following 2 chains:Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment

产品基因名称 :

RET

其他基因名称 :

RET;RET;PTC;MTC1;HSCR1;多发性内分泌腺瘤2a型;多发性内分泌腺瘤2b型;RET51;CDHF12;CDHR16;RET-ELE1;CDHF12;CDHR16;PTC;RET51

UniProt数据库进入名 :

RET_HUMAN

克隆性 :

单克隆

克隆 :

8D10C9

宿主 :

小鼠

反应物种 :

人类

序列长度 :

1072

形式 :

腹水含0.03% 叠氮化钠

浓度 :

100微克/100微升

储存稳定性 :

Store at 4 degree C. For long term storage, store at -20 degree C

检测过的应用 :

免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)

应用笔记 :

WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test.

其他信息2 :

Immunogen: Purified recombinant fragment of RET (aa896-1063) expressed in E. Coli. Species: Mouse IgG1

产品种类 :

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

产品描述 :

Background: RET (ret proto-oncogene) is a member of the cadherin superfamily and a receptor tyrosine kinase, which are cell-surface molecules that transduce signals for cell growth and differentiation. It can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung's disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.

NCBI GI登录号 :

10862701

NCBI登录号 :

NP_065681.1

NCBI基因登录号 :

NM_020630.4

NCBI分子量 :

119,847 Da

NCBI信号通路 :

Endocytosis Pathway (102279); Endocytosis Pathway (102181); Pathways In Cancer (83105); SIDS Susceptibility Pathways (198901); Signaling Events Regulated By Ret Tyrosine Kinase Pathway (137915); Thyroid Cancer Pathway (83112); Thyroid Cancer Pathway (524)

NCBI总结 :

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]

UniProt数据库总结 :

Ret: a proto-oncogenic receptor tyrosine kinase. Receptor for glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Part of a multicompetent receptor complex with other membrane-bound ligand-binding GDNF family receptors (aGFRs). Required for development of the kidney and neural crest-derived cell types. Three alternatively spliced isoforms have been described. Protein type: Oncoprotein; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; TK group; Ret family. Chromosomal Location of Human Ortholog: 10q11.2. Cellular Component: intracellular membrane-bound organelle; integral to plasma membrane; cytoplasm; plasma membrane; endosome membrane; receptor complex; lipid raft. Molecular Function: protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; calcium ion binding; receptor activity; ATP binding. Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of cell size; positive regulation of transcription, DNA-dependent; membrane protein proteolysis; response to pain; signal transduction; regulation of axonogenesis; enteric nervous system development; neuron maturation; protein amino acid phosphorylation; ureteric bud development; embryonic epithelial tube formation; neuron adhesion; neural crest cell migration; regulation of cell adhesion; caspase activation; response to drug; posterior midgut development; positive regulation of neuron maturation; MAPKKK cascade; positive regulation of cell adhesion mediated by integrin; retina development in camera-type eye; homophilic cell adhesion; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration. Disease: Multiple Endocrine Neoplasia, Type Iib; Multiple Endocrine Neoplasia, Type Iia; Thyroid Carcinoma, Papillary; Hirschsprung Disease, Susceptibility To, 1; Thyroid Carcinoma, Familial Medullary

尺寸1 :

0.1毫克

价格1 :

290美元

更多信息或购买 :

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公司信息