抗体

KI67抗体

MBS850259

0.1毫克

280美元

单克隆

小鼠

未共轭

[9C12B2]

免疫印迹, 酶联免疫吸附测定, 酶免疫法

抗体

KI67抗体

[KI67]

[KIA;Ki67抗原;MKI67]

[proliferation marker protein Ki-67 isoform 2; Proliferation marker protein Ki-67; proliferation marker protein Ki-67; marker of proliferation Ki-67; Antigen identified by monoclonal antibody Ki-67]

[KI67]

[MKI67;MKI67;KIA;MIB-;MIB-1;PPP1R105;抗原KI-67Curated;抗原Ki67Curated]

m

IgG1

[9C12B2]

小鼠

人类

2896

腹水含0.03% 叠氮化钠

Store at 4 degree C, for long term storage, store at-20 degree C

免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)

WB: 1:500-1:2000。 ELISA: 1:10000

免疫印迹(免疫印迹)

Immunogen: Purified recombinant fragment of Ki167 (aa3118-3256) expressed in E. Coli.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Ki67. antigen identified by monoclonal antibody Ki-67. Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.

225543215

NP_001139438.1

NM_001145966.1

P46013

319,444 Da

This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

0.1毫克

280美元