产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
OCT4抗体
目录 :
MBS850273
规格 :
0.1毫克
价格 :
290美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
5F7
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
MBS850273
产品类型 :
抗体
产品全称 :
OCT4抗体
产品简称 :
4-Oct
产品名称同义词 :
OCT3; OCT4; OTF3; OTF4; OTF-3; Oct-3; Oct-4; MGC22487; POU5F1
其他名称 :
POU domain, class 5, transcription factor 1 isoform 2; POU domain, class 5, transcription factor 1; POU domain, class 5, transcription factor 1; octamer-binding protein 3; octamer-binding protein 4; POU domain transcription factor OCT4; octamer-binding transcription factor 3; POU-type homeodomain-containing DNA-binding protein; POU class 5 homeobox 1; Octamer-binding protein 3; Oct-3; Octamer-binding protein 4; Oct-4; Octamer-binding transcription factor 3; OTF-3
产品基因名称 :
4-Oct
其他基因名称 :
POU5F1; POU5F1; OCT3; OCT4; OTF3; OTF4; OTF-3; Oct-3; Oct-4; OCT3; OCT4; OTF3; Oct-3; Oct-4; OTF-3
UniProt数据库进入名 :
PO5F1_HUMAN
克隆性 :
单克隆
克隆 :
5F7
宿主 :
小鼠
反应物种 :
人类
序列长度 :
190
形式 :
腹水含0.03% 叠氮化钠
浓度 :
100微克/100微升
储存稳定性 :
Store at 4 degree C, for long term storage, store at -20 degree C.
检测过的应用 :
免疫印迹(免疫印迹), 酶联免疫吸附测定(EIA)。 尚未在其他应用中测试
应用笔记 :
WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000
其他信息2 :
Immunogen: Synthesized peptide of human Oct4. Species: Mouse IgG1
产品种类 :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
产品描述 :
Background: This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. (provided by RefSeq).Tissue specificity: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.
NCBI GI登录号 :
291167757
NCBI登录号 :
NP_001167002.1
NCBI基因登录号 :
NM_001173531.2
NCBI分子量 :
45kDa
NCBI信号通路 :
Cardiac Progenitor Differentiation Pathway (712094); Developmental Biology Pathway (477129); HIF-2-alpha Transcription Factor Network Pathway (137956); POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway (980456); POU5F1 (OCT4), SOX2, NANOG Repress Genes Related To Differentiation Pathway (980457); SIDS Susceptibility Pathways (198901); Signaling Pathways Regulating Pluripotency Of Stem Cells (1026136); Signaling Pathways Regulating Pluripotency Of Stem Cells (1033502); Transcriptional Regulation Of Pluripotent Stem Cells Pathway (980455); Wnt Signaling Pathway And Pluripotency (198847)
NCBI总结 :
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]
UniProt数据库总结 :
Oct4: Transcription factor that binds to the octamer motif (5 -ATTTGCAT-3 ). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Interacts with UBE2I and ZSCAN10. Interacts with PKM2. Interacts with WWP2. Transcriptional activity is positively regulated by PKM2. Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues. Belongs to the POU transcription factor family. Class- 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 6p21.31. Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus; cytosol. Molecular Function: protein binding; miRNA binding; DNA binding; sequence-specific DNA binding; ubiquitin protein ligase binding; transcription factor binding; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; anatomical structure morphogenesis; blastocyst development; regulation of asymmetric cell division; regulation of transcription, DNA-dependent; regulation of gene expression; somatic stem cell maintenance; endodermal cell fate specification; response to wounding; positive regulation of transcription from RNA polymerase II promoter; mRNA transcription from RNA polymerase II promoter
尺寸1 :
0.1毫克
价格1 :
290美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。