产品简要
公司名称 :
MyBioSource
产品类型 :
抗体
产品名称 :
缺氧诱导因子1A抗体
目录 :
MBS850472
规格 :
0.1毫克
价格 :
290美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
1A3
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 酶免疫法
更多信息或购买 :
产品信息
目录号 :
MBS850472
产品类型 :
抗体
产品全称 :
缺氧诱导因子1A抗体
产品简称 :
缺氧诱导因子1A
产品名称同义词 :
HIF1;MOP1;PASD8;bHLHe78;HIF-1alpha;HIF1-甲;缺氧诱导因子1A
其他名称 :
hypoxia-inducible factor 1-alpha isoform 3; Hypoxia-inducible factor 1-alpha; hypoxia-inducible factor 1-alpha; HIF-1-alpha; member of PAS protein 1; ARNT interacting protein; ARNT-interacting protein; member of PAS superfamily 1; hypoxia-inducible factor1alpha; PAS domain-containing protein 8; basic-helix-loop-helix-PAS protein MOP1; class E basic helix-loop-helix protein 78; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; bHLHe78; Member of PAS protein 1; PAS domain-containing protein 8
产品基因名称 :
缺氧诱导因子1A
其他基因名称 :
缺氧诱导因子1A;缺氧诱导因子1A;HIF1;MOP1;PASD8;HIF-1A;bHLHe78;HIF-1alpha;HIF1-甲;BHLHE78;MOP1;PASD8;HIF-1;HIF1甲;bHLHe78
UniProt数据库进入名 :
HIF1A_HUMAN
克隆性 :
单克隆
克隆 :
1A3
宿主 :
小鼠
反应物种 :
Human, Mouse, Monkey
序列长度 :
850
形式 :
腹水含0.03% 叠氮化钠
浓度 :
100微克/100微升
储存稳定性 :
Store at 4 degree C, for long term storage, store at -20 degree C.
检测过的应用 :
免疫印迹(免疫印迹), 免疫组化(免疫组化), 免疫荧光(IF), 酶联免疫吸附测定(EIA)
应用笔记 :
WB: 1/500 - 1/2000, IHC: 1/200-1/1000, IF: 1/200-1/1000, ELISA: Propose dilution 1/10000. Not yet tested in other applications.
其他信息2 :
Immunogen: Purified recombinant fragment of human HIF1A expressed in E. Coli. Species: Mouse IgG1
产品种类 :
Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
产品描述 :
Background: Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified. (provided by RefSeq) Tissue specificity: Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors.
NCBI GI登录号 :
340545531
NCBI登录号 :
NP_001230013.1
NCBI基因登录号 :
NM_001243084.1
NCBI分子量 :
120kDa
NCBI信号通路 :
AGE/RAGE Pathway 698754!!Adipogenesis Pathway 198832!!Angiogenesis Pathway 198772!!Cellular Response To Hypoxia Pathway 645259!!Cellular Responses To Stress Pathway 645258!!Circadian Clock Pathway 187173!!Disease Pathway 530764!!FBXW7 Mutants And NOTCH1 In Cancer Pathway 771596!!HIF-1 Signaling Pathway 695200!!HIF-1-alpha Transcription Factor Network Pathway 138045
NCBI总结 :
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
规格 :
0.1毫克
价格 :
290美元
更多信息或购买 :
公司信息
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-858-633-0165
公司总部: 美国
MyBioSource,LLC最初由三名热情澎湃的提供高品质试剂的科学家联合创立于温哥华,公司愿景是“生物研究试剂的源头”,现在位于圣地亚哥市。