抗体

HNF4A抗体

MBS8505949

0.1毫升

310美元

多克隆

兔

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化

抗体

HNF4A抗体

[HNF4A]

[HNF4A;HNF4;HNF4a7;HNF4a8;HNF4a9;HNF4alpha;MODY;MODY1;NR2A1;NR2A21;TCF;TCF14]

[hepatocyte nuclear factor 4-alpha 2; Hepatocyte nuclear factor 4-alpha; hepatocyte nuclear factor 4-alpha; hepatocyte nuclear factor 4 alpha; Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4]

[HNF4A]

[HNF4A;HNF4A;TCF;HNF4;MODY;FRTS4;MODY1;NR2A1;TCF14;HNF4a7;HNF4a8;HNF4a9;NR2A21;HNF4alpha;HNF4;NR2A1;TCF14;HNF-4-alpha;TCF-14]

多克隆

IgG

兔

人类, 小鼠, 大鼠

474

亲和纯化

Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.

免疫印迹(免疫印迹), 免疫组化(免疫组化)

WB: 1:500-1:2000。 IHC: 1:50-1:200

试验数据

Immunogen: A synthetic peptide of human HNF4A. Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Hepatocyte nuclear factor 4alpha (HNF4alpha) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver (1). HNF4alpha, in association with PGC-1alpha, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers (2, 3). Conditional knockout of the HNF4alpha gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels (4). Mutations in HNF4alpha have been linked to maturity-onset diabetes of the young (MODY) (5).

1. Sladek, F.M. et al. (1990) Genes Dev. 4, 2353-2365. 2. Yoon, J.C. et al. (2001) Nature 413, 131-138. 3. Rhee, J. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 4012-4017. 4. Hayhurst, G.P. et al. (2001) Mol. Cell Biol. 21, 1393-1403. 5. Ellard, S. and Colclough, K. (2006) Hum. Mutat. 27, 854-869.

31077205

NP_000448.3

NM_000457.4

P41235

52kDa

AMPK Signaling Pathway (198868); Developmental Biology Pathway (477129); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); HIF-1-alpha Transcription Factor Network Pathway (138045); Integrated Pancreatic Cancer Pathway (711360); Maturity Onset Diabetes Of The Young Pathway (83096); Maturity Onset Diabetes Of The Young Pathway (508); Nuclear Receptor Transcription Pathway (105979)

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.

0.1毫升

310美元